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Importance of Nano Medicine and New Drug Therapies for Cancer

Cancer is one of the deadly diseases leading to approximately 7.6 million deaths worldwide, with the mortality rate of 13%, and the number of deaths is expected to increase to 13.1 million within the next 10 years. In controlled drug delivery systems (DDS), the drug is transported to the desired loc...

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Autores principales: Abdolmaleki, Arash, Asadi, Asadollah, Gurushankar, Krishnamoorthy, Karimi Shayan, Tahereh, Abedi Sarvestani, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421622/
https://www.ncbi.nlm.nih.gov/pubmed/34513619
http://dx.doi.org/10.34172/apb.2021.052
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author Abdolmaleki, Arash
Asadi, Asadollah
Gurushankar, Krishnamoorthy
Karimi Shayan, Tahereh
Abedi Sarvestani, Fatemeh
author_facet Abdolmaleki, Arash
Asadi, Asadollah
Gurushankar, Krishnamoorthy
Karimi Shayan, Tahereh
Abedi Sarvestani, Fatemeh
author_sort Abdolmaleki, Arash
collection PubMed
description Cancer is one of the deadly diseases leading to approximately 7.6 million deaths worldwide, with the mortality rate of 13%, and the number of deaths is expected to increase to 13.1 million within the next 10 years. In controlled drug delivery systems (DDS), the drug is transported to the desired location. Thus, the influence of drugs on vital tissues and undesirable side effects can be minimised. Additionally, DDS protects the drug from rapid degradation or clearance and enhances drug concentration in target tissues, and therefore, minimise the required dose of drug. This modern form of therapy is particularly important when there is a discrepancy between the dose and concentration of a drug. Cell-specific targeting can be achieved by attaching drugs to individually designed carriers. Recent developments in nanotechnology have shown that nanoparticles (particles with diameter < 100 nm in at least one dimension) have great potential as drug carriers. Because of their small size, these nanostructures exhibit unique physicochemical and biological properties that make them a favourable material for biomedical applications. Therefore, in this review, we aimed to describe the importance and types of nanomedicines and efficient ways in which new drug delivery systems for the treatment of cancer can be developed.
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spelling pubmed-84216222021-09-09 Importance of Nano Medicine and New Drug Therapies for Cancer Abdolmaleki, Arash Asadi, Asadollah Gurushankar, Krishnamoorthy Karimi Shayan, Tahereh Abedi Sarvestani, Fatemeh Adv Pharm Bull Mini Review Cancer is one of the deadly diseases leading to approximately 7.6 million deaths worldwide, with the mortality rate of 13%, and the number of deaths is expected to increase to 13.1 million within the next 10 years. In controlled drug delivery systems (DDS), the drug is transported to the desired location. Thus, the influence of drugs on vital tissues and undesirable side effects can be minimised. Additionally, DDS protects the drug from rapid degradation or clearance and enhances drug concentration in target tissues, and therefore, minimise the required dose of drug. This modern form of therapy is particularly important when there is a discrepancy between the dose and concentration of a drug. Cell-specific targeting can be achieved by attaching drugs to individually designed carriers. Recent developments in nanotechnology have shown that nanoparticles (particles with diameter < 100 nm in at least one dimension) have great potential as drug carriers. Because of their small size, these nanostructures exhibit unique physicochemical and biological properties that make them a favourable material for biomedical applications. Therefore, in this review, we aimed to describe the importance and types of nanomedicines and efficient ways in which new drug delivery systems for the treatment of cancer can be developed. Tabriz University of Medical Sciences 2021-06 2020-10-19 /pmc/articles/PMC8421622/ /pubmed/34513619 http://dx.doi.org/10.34172/apb.2021.052 Text en ©2021 The Authors. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, as long as the original authors and source are cited. No permission is required from the authors or the publishers.
spellingShingle Mini Review
Abdolmaleki, Arash
Asadi, Asadollah
Gurushankar, Krishnamoorthy
Karimi Shayan, Tahereh
Abedi Sarvestani, Fatemeh
Importance of Nano Medicine and New Drug Therapies for Cancer
title Importance of Nano Medicine and New Drug Therapies for Cancer
title_full Importance of Nano Medicine and New Drug Therapies for Cancer
title_fullStr Importance of Nano Medicine and New Drug Therapies for Cancer
title_full_unstemmed Importance of Nano Medicine and New Drug Therapies for Cancer
title_short Importance of Nano Medicine and New Drug Therapies for Cancer
title_sort importance of nano medicine and new drug therapies for cancer
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421622/
https://www.ncbi.nlm.nih.gov/pubmed/34513619
http://dx.doi.org/10.34172/apb.2021.052
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