Cargando…

Protective effects of curcumin against methotrexate-induced testicular damage in rats by suppression of the p38-MAPK and nuclear factor-kappa B pathways

OBJECTIVE: The present study aimed to investigate the possibility that curcumin (CMN) protects against methotrexate (MTX)-induced testicular damage by affecting the phospho-p38 (p-p38) mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways. METHODS: Eighteen ma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kilinc, Leyla, Uz, Yesim Hulya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Reproductive Medicine 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421662/ https://www.ncbi.nlm.nih.gov/pubmed/34352168 http://dx.doi.org/10.5653/cerm.2020.04105

Ejemplares similares

Nuclear Localization of p38 MAPK in Response to DNA Damage
por: Wood, C. David, et al.
Publicado: (2009)

Protective Effect of Curcumin against Sodium Salicylate-Induced Oxidative Kidney Damage, Nuclear Factor-Kappa Dysregulation, and Apoptotic Consequences in Rats
por: Abd-Elhakim, Yasmina M., et al.
Publicado: (2021)

Bridelia ferruginea Produces Antineuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling
por: Olajide, Olumayokun A., et al.
Publicado: (2012)

Effects of Resveratrol on Methotrexate-Induced Testicular Damage in Rats
por: Yuluğ, Esin, et al.
Publicado: (2013)

Protective effect of melatonin against methotrexate-induced testicular damage in the rat model: An experimental study
por: Sukhorum, Wannisa, et al.
Publicado: (2020)

Protective Effects of the Nuclear Factor Kappa B Inhibitor Pyrrolidine Dithiocarbamate on Experimental Testicular Torsion and Detorsion Injury
por: Kabay, Sahin, et al.
Publicado: (2014)

Loganin alleviates testicular damage and germ cell apoptosis induced by AGEs upon diabetes mellitus by suppressing the RAGE/p38MAPK/NF‐κB pathway
por: Chen, Yuping, et al.
Publicado: (2020)

Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes
por: Gonzales, Amanda M, et al.
Publicado: (2008)

Cancer suppression by systemic inactivation of p38MAPK
por: Brichkina, Anna, et al.
Publicado: (2017)

Curcumin suppresses cardiac fibroblasts activities by regulating the proliferation and cell cycle via the inhibition of the p38 MAPK/ERK signaling pathway
por: Fang, Guanhua, et al.
Publicado: (2018)

Protective effect of royal jelly in 2,4,6 trinitrobenzene sulfonic acid-induced colitis in rats
por: Karaca, Turan, et al.
Publicado: (2015)

β-Cyclodextrin Modified Hydrogels of Kappa-Carrageenan for Methotrexate Delivery
por: Nikitina, Maria, et al.
Publicado: (2023)

Tumour Necrosis Factor-alpha and Nuclear Factor-kappa B Gene Variants in Sepsis
por: Acar, Leyla, et al.
Publicado: (2018)

Curcumin Ameliorates Methotrexate-Induced Nephrotoxicity in Rats
por: Morsy, Mohamed A., et al.
Publicado: (2013)

Compound Porcine Cerebroside and Ganglioside Injection (CPCGI) Attenuates Sevoflurane-Induced Nerve Cell Injury by Regulating the Phosphorylation of p38 MAP Kinase (p38MAPK)/Nuclear Factor kappa B (NF-κB) Pathway
por: Song, Haigang, et al.
Publicado: (2020)

Protective effect of curcumin on lead acetate-induced testicular toxicity in Wistar rats
por: Sudjarwo, Sri Agus, et al.
Publicado: (2017)

Protective effects of Curcumin on testicular toxicity induced by titanium dioxide nanoparticles in mice
por: Karimi, Samaneh, et al.
Publicado: (2019)

Nuclear Factor kappa B (NF-κB) Targeted Self-Assembled Nanoparticles Loaded with Methotrexate for Treatment of Rheumatoid Arthritis
por: Li, Xiong, et al.
Publicado: (2019)

Curcumin Induces Apoptosis of Chemoresistant Lung Cancer Cells via ROS-Regulated p38 MAPK Phosphorylation
por: Wu, Ming-Fang, et al.
Publicado: (2022)

Curcumin attenuates gentamicin and sodium salicylate ototoxic effects by modulating the nuclear factor-kappaB and apoptotic pathways in rats
por: Abd-Elhakim, Yasmina M., et al.
Publicado: (2022)

Protective effects of apocynin on damaged testes of rats exposed to methotrexate
por: KAVRAM SARIHAN, Kübra, et al.
Publicado: (2020)

Soy Isoflavones Protect Neuronal PC12 Cells against Hypoxic Damage through Nrf2 Activation and Suppression of p38 MAPK and AKT–mTOR Pathways
por: Zhang, Yongzhu, et al.
Publicado: (2022)

p38 MAPK in MDS
por: Gañán‐Gómez, Irene, et al.
Publicado: (2015)

DNA damage-induced nuclear factor-kappa B activation and its roles in cancer progression
por: Wang, Wei, et al.
Publicado: (2017)

The Possible Contribution of P-Glycoprotein in the Protective Effect of Paeonol against Methotrexate-Induced Testicular Injury in Rats
por: Morsy, Mohamed A., et al.
Publicado: (2020)

l-Menthol alleviates cigarette smoke extract induced lung injury in rats by inhibiting oxidative stress and inflammation via nuclear factor kappa B, p38 MAPK and Nrf2 signalling pathways
por: Liu, Yan, et al.
Publicado: (2018)

Haemozoin Induces Early Cytokine-Mediated Lysozyme Release from Human Monocytes through p38 MAPK- and NF-kappaB- Dependent Mechanisms
por: Polimeni, Manuela, et al.
Publicado: (2012)

Aplysin Sensitizes Cancer Cells to TRAIL by Suppressing P38 MAPK/Survivin Pathway
por: Liu, Jia, et al.
Publicado: (2014)

Targeted ablation of p38α MAPK suppresses denervation-induced muscle atrophy
por: Yuasa, Kazuki, et al.
Publicado: (2018)

Aprepitant Inhibits JNK and p38/MAPK to Attenuate Inflammation and Suppresses Inflammatory Pain
por: Yang, Yang, et al.
Publicado: (2022)

Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B
por: Xu, Feng, et al.
Publicado: (2008)

The Effect of Thymoquinone on Nuclear Factor Kappa B Levels and Oxidative DNA Damage on Experimental Diabetic Rats
por: Usta, Ayşe, et al.
Publicado: (2017)

The Role of G3BP1 Gene Mediates P38 MAPK/JNK Pathway in Testicular Spermatogenic Dysfunction Caused by Cyfluthrin
por: Li, Xiao-Yu, et al.
Publicado: (2023)

Protective effects of curcumin on chromatin quality, sperm parameters, and apoptosis following testicular torsion-detorsion in mice
por: Shahedi, Abbas, et al.
Publicado: (2021)

Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology
por: Maphis, Nicole, et al.
Publicado: (2016)

Anti-Inflammatory Effect of Geniposide on Osteoarthritis by Suppressing the Activation of p38 MAPK Signaling Pathway
por: Chen, Yuan, et al.
Publicado: (2018)

Knockdown of Heparanase Suppresses Invasion of Human Trophoblasts by Activating p38 MAPK Signaling Pathway
por: Che, Guanglu, et al.
Publicado: (2018)

High Glucose Suppresses Keratinocyte Migration Through the Inhibition of p38 MAPK/Autophagy Pathway
por: Li, Lingfei, et al.
Publicado: (2019)

Bakuchiol Suppresses Inflammatory Responses Via the Downregulation of the p38 MAPK/ERK Signaling Pathway
por: Lim, Hye-Sun, et al.
Publicado: (2019)

Stress-specific p38 MAPK activation is sufficient to drive EGFR endocytosis but not its nuclear translocation
por: Tomas, Alejandra, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_kumfb5k95se28ogugu9n92hp4u