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Case Report: Alpelisib-Induced Drug Reaction With Eosinophilia and Systemic Symptoms: A Rare Manifestation of a Common Side Effect

Alpelisib is a PIK3a inhibitor approved for the treatment of metastatic ER+ breast cancer in combination with fulvestrant. Although rash is a common side effect of this medication, we present the first case of drug reaction with eosinophilia and systemic symptoms (DRESS) upon initial exposure to alp...

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Autores principales: Majeed, Umair, Puiu, Tudor, Sluzevich, Jason, Reynolds, Gina, Acampora, Marites, Moreno-Aspitia, Alvaro, Bodiford, Katherine J., Advani, Pooja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421674/
https://www.ncbi.nlm.nih.gov/pubmed/34504802
http://dx.doi.org/10.3389/fonc.2021.726785
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author Majeed, Umair
Puiu, Tudor
Sluzevich, Jason
Reynolds, Gina
Acampora, Marites
Moreno-Aspitia, Alvaro
Bodiford, Katherine J.
Advani, Pooja
author_facet Majeed, Umair
Puiu, Tudor
Sluzevich, Jason
Reynolds, Gina
Acampora, Marites
Moreno-Aspitia, Alvaro
Bodiford, Katherine J.
Advani, Pooja
author_sort Majeed, Umair
collection PubMed
description Alpelisib is a PIK3a inhibitor approved for the treatment of metastatic ER+ breast cancer in combination with fulvestrant. Although rash is a common side effect of this medication, we present the first case of drug reaction with eosinophilia and systemic symptoms (DRESS) upon initial exposure to alpelisib. Here we describe the clinical-pathological findings and management of our patient with alpelisib-induced life-threatening DRESS syndrome. The goal of this case report is to highlight association of alpelisib with DRESS syndrome, in clinical practice, so that alpelisib can be immediately stopped and treatment for this serious condition promptly initiated.
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spelling pubmed-84216742021-09-08 Case Report: Alpelisib-Induced Drug Reaction With Eosinophilia and Systemic Symptoms: A Rare Manifestation of a Common Side Effect Majeed, Umair Puiu, Tudor Sluzevich, Jason Reynolds, Gina Acampora, Marites Moreno-Aspitia, Alvaro Bodiford, Katherine J. Advani, Pooja Front Oncol Oncology Alpelisib is a PIK3a inhibitor approved for the treatment of metastatic ER+ breast cancer in combination with fulvestrant. Although rash is a common side effect of this medication, we present the first case of drug reaction with eosinophilia and systemic symptoms (DRESS) upon initial exposure to alpelisib. Here we describe the clinical-pathological findings and management of our patient with alpelisib-induced life-threatening DRESS syndrome. The goal of this case report is to highlight association of alpelisib with DRESS syndrome, in clinical practice, so that alpelisib can be immediately stopped and treatment for this serious condition promptly initiated. Frontiers Media S.A. 2021-08-24 /pmc/articles/PMC8421674/ /pubmed/34504802 http://dx.doi.org/10.3389/fonc.2021.726785 Text en Copyright © 2021 Majeed, Puiu, Sluzevich, Reynolds, Acampora, Moreno-Aspitia, Bodiford and Advani https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Majeed, Umair
Puiu, Tudor
Sluzevich, Jason
Reynolds, Gina
Acampora, Marites
Moreno-Aspitia, Alvaro
Bodiford, Katherine J.
Advani, Pooja
Case Report: Alpelisib-Induced Drug Reaction With Eosinophilia and Systemic Symptoms: A Rare Manifestation of a Common Side Effect
title Case Report: Alpelisib-Induced Drug Reaction With Eosinophilia and Systemic Symptoms: A Rare Manifestation of a Common Side Effect
title_full Case Report: Alpelisib-Induced Drug Reaction With Eosinophilia and Systemic Symptoms: A Rare Manifestation of a Common Side Effect
title_fullStr Case Report: Alpelisib-Induced Drug Reaction With Eosinophilia and Systemic Symptoms: A Rare Manifestation of a Common Side Effect
title_full_unstemmed Case Report: Alpelisib-Induced Drug Reaction With Eosinophilia and Systemic Symptoms: A Rare Manifestation of a Common Side Effect
title_short Case Report: Alpelisib-Induced Drug Reaction With Eosinophilia and Systemic Symptoms: A Rare Manifestation of a Common Side Effect
title_sort case report: alpelisib-induced drug reaction with eosinophilia and systemic symptoms: a rare manifestation of a common side effect
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421674/
https://www.ncbi.nlm.nih.gov/pubmed/34504802
http://dx.doi.org/10.3389/fonc.2021.726785
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