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When Leptin Is Not There: A Review of What Nonsyndromic Monogenic Obesity Cases Tell Us and the Benefits of Exogenous Leptin

Obesity is a pandemic condition of complex etiology, resulting from the increasing exposition to obesogenic environmental factors combined with genetic susceptibility. In the past two decades, advances in genetic research identified variants of the leptin-melanocortin pathway coding for genes, which...

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Autores principales: Salum, Kaio Cezar Rodrigues, Rolando, Jônatas de Mendonça, Zembrzuski, Verônica Marques, Carneiro, João Regis Ivar, Mello, Cicero Brasileiro, Maya-Monteiro, Clarissa Menezes, Bozza, Patrícia Torres, Kohlrausch, Fabiana Barzotto, da Fonseca, Ana Carolina Proença
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421737/
https://www.ncbi.nlm.nih.gov/pubmed/34504472
http://dx.doi.org/10.3389/fendo.2021.722441
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author Salum, Kaio Cezar Rodrigues
Rolando, Jônatas de Mendonça
Zembrzuski, Verônica Marques
Carneiro, João Regis Ivar
Mello, Cicero Brasileiro
Maya-Monteiro, Clarissa Menezes
Bozza, Patrícia Torres
Kohlrausch, Fabiana Barzotto
da Fonseca, Ana Carolina Proença
author_facet Salum, Kaio Cezar Rodrigues
Rolando, Jônatas de Mendonça
Zembrzuski, Verônica Marques
Carneiro, João Regis Ivar
Mello, Cicero Brasileiro
Maya-Monteiro, Clarissa Menezes
Bozza, Patrícia Torres
Kohlrausch, Fabiana Barzotto
da Fonseca, Ana Carolina Proença
author_sort Salum, Kaio Cezar Rodrigues
collection PubMed
description Obesity is a pandemic condition of complex etiology, resulting from the increasing exposition to obesogenic environmental factors combined with genetic susceptibility. In the past two decades, advances in genetic research identified variants of the leptin-melanocortin pathway coding for genes, which are related to the potentiation of satiety and hunger, immune system, and fertility. Here, we review cases of congenital leptin deficiency and the possible beneficial effects of leptin replacement therapy. In summary, the cases presented here show clinical phenotypes of disrupted bodily energy homeostasis, biochemical and hormonal disorders, and abnormal immune response. Some phenotypes can be partially reversed by exogenous administration of leptin. With this review, we aim to contribute to the understanding of leptin gene mutations as targets for obesity diagnostics and treatment strategies.
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spelling pubmed-84217372021-09-08 When Leptin Is Not There: A Review of What Nonsyndromic Monogenic Obesity Cases Tell Us and the Benefits of Exogenous Leptin Salum, Kaio Cezar Rodrigues Rolando, Jônatas de Mendonça Zembrzuski, Verônica Marques Carneiro, João Regis Ivar Mello, Cicero Brasileiro Maya-Monteiro, Clarissa Menezes Bozza, Patrícia Torres Kohlrausch, Fabiana Barzotto da Fonseca, Ana Carolina Proença Front Endocrinol (Lausanne) Endocrinology Obesity is a pandemic condition of complex etiology, resulting from the increasing exposition to obesogenic environmental factors combined with genetic susceptibility. In the past two decades, advances in genetic research identified variants of the leptin-melanocortin pathway coding for genes, which are related to the potentiation of satiety and hunger, immune system, and fertility. Here, we review cases of congenital leptin deficiency and the possible beneficial effects of leptin replacement therapy. In summary, the cases presented here show clinical phenotypes of disrupted bodily energy homeostasis, biochemical and hormonal disorders, and abnormal immune response. Some phenotypes can be partially reversed by exogenous administration of leptin. With this review, we aim to contribute to the understanding of leptin gene mutations as targets for obesity diagnostics and treatment strategies. Frontiers Media S.A. 2021-08-24 /pmc/articles/PMC8421737/ /pubmed/34504472 http://dx.doi.org/10.3389/fendo.2021.722441 Text en Copyright © 2021 Salum, Rolando, Zembrzuski, Carneiro, Mello, Maya-Monteiro, Bozza, Kohlrausch and da Fonseca https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Salum, Kaio Cezar Rodrigues
Rolando, Jônatas de Mendonça
Zembrzuski, Verônica Marques
Carneiro, João Regis Ivar
Mello, Cicero Brasileiro
Maya-Monteiro, Clarissa Menezes
Bozza, Patrícia Torres
Kohlrausch, Fabiana Barzotto
da Fonseca, Ana Carolina Proença
When Leptin Is Not There: A Review of What Nonsyndromic Monogenic Obesity Cases Tell Us and the Benefits of Exogenous Leptin
title When Leptin Is Not There: A Review of What Nonsyndromic Monogenic Obesity Cases Tell Us and the Benefits of Exogenous Leptin
title_full When Leptin Is Not There: A Review of What Nonsyndromic Monogenic Obesity Cases Tell Us and the Benefits of Exogenous Leptin
title_fullStr When Leptin Is Not There: A Review of What Nonsyndromic Monogenic Obesity Cases Tell Us and the Benefits of Exogenous Leptin
title_full_unstemmed When Leptin Is Not There: A Review of What Nonsyndromic Monogenic Obesity Cases Tell Us and the Benefits of Exogenous Leptin
title_short When Leptin Is Not There: A Review of What Nonsyndromic Monogenic Obesity Cases Tell Us and the Benefits of Exogenous Leptin
title_sort when leptin is not there: a review of what nonsyndromic monogenic obesity cases tell us and the benefits of exogenous leptin
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421737/
https://www.ncbi.nlm.nih.gov/pubmed/34504472
http://dx.doi.org/10.3389/fendo.2021.722441
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