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Case Report: Metastatic Parosteal Osteosarcoma in a Dog

This case report describes a rare form of malignant bone tumor in an 8-year-old Labrador retriever. This dog initially presented for evaluation of a right distal humeral mass. Radiographs of the right elbow and thorax were performed, revealing a smooth mineralized mass adjacent to the lateral aspect...

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Autores principales: Samuels, Sarah K., Cook, Matthew R., Green, Eric, Jennings, Ryan, Pool, Roy R., Wavreille, Vincent A., Kisseberth, William C., Selmic, Laura E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421772/
https://www.ncbi.nlm.nih.gov/pubmed/34504888
http://dx.doi.org/10.3389/fvets.2021.715908
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author Samuels, Sarah K.
Cook, Matthew R.
Green, Eric
Jennings, Ryan
Pool, Roy R.
Wavreille, Vincent A.
Kisseberth, William C.
Selmic, Laura E.
author_facet Samuels, Sarah K.
Cook, Matthew R.
Green, Eric
Jennings, Ryan
Pool, Roy R.
Wavreille, Vincent A.
Kisseberth, William C.
Selmic, Laura E.
author_sort Samuels, Sarah K.
collection PubMed
description This case report describes a rare form of malignant bone tumor in an 8-year-old Labrador retriever. This dog initially presented for evaluation of a right distal humeral mass. Radiographs of the right elbow and thorax were performed, revealing a smooth mineralized mass adjacent to the lateral aspect of the distal humerus and a 5mm pulmonary nodule. Computed tomography (CT) of the humerus and thorax showed a smooth mineralized lesion adjacent to the lateral humeral epicondyle, and a right cranial lung lobe nodule with a thin mineral rim. Surgical biopsies of both lesions were diagnostic for parosteal osteosarcoma (POSA). The dog was then treated with stereotactic body radiation therapy (SBRT) which controlled the dog's discomfort for 14 months until he became progressively painful and subsequently had his right forelimb amputated. This case report is the first to document the CT imaging characteristics of a metastatic appendicular POSA in a dog and the first dog described with POSA treated with SBRT. The dog lived for 623 days after histopathologic diagnosis and 849 days after initial presentation with pulmonary metastatic disease.
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spelling pubmed-84217722021-09-08 Case Report: Metastatic Parosteal Osteosarcoma in a Dog Samuels, Sarah K. Cook, Matthew R. Green, Eric Jennings, Ryan Pool, Roy R. Wavreille, Vincent A. Kisseberth, William C. Selmic, Laura E. Front Vet Sci Veterinary Science This case report describes a rare form of malignant bone tumor in an 8-year-old Labrador retriever. This dog initially presented for evaluation of a right distal humeral mass. Radiographs of the right elbow and thorax were performed, revealing a smooth mineralized mass adjacent to the lateral aspect of the distal humerus and a 5mm pulmonary nodule. Computed tomography (CT) of the humerus and thorax showed a smooth mineralized lesion adjacent to the lateral humeral epicondyle, and a right cranial lung lobe nodule with a thin mineral rim. Surgical biopsies of both lesions were diagnostic for parosteal osteosarcoma (POSA). The dog was then treated with stereotactic body radiation therapy (SBRT) which controlled the dog's discomfort for 14 months until he became progressively painful and subsequently had his right forelimb amputated. This case report is the first to document the CT imaging characteristics of a metastatic appendicular POSA in a dog and the first dog described with POSA treated with SBRT. The dog lived for 623 days after histopathologic diagnosis and 849 days after initial presentation with pulmonary metastatic disease. Frontiers Media S.A. 2021-08-24 /pmc/articles/PMC8421772/ /pubmed/34504888 http://dx.doi.org/10.3389/fvets.2021.715908 Text en Copyright © 2021 Samuels, Cook, Green, Jennings, Pool, Wavreille, Kisseberth and Selmic. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Samuels, Sarah K.
Cook, Matthew R.
Green, Eric
Jennings, Ryan
Pool, Roy R.
Wavreille, Vincent A.
Kisseberth, William C.
Selmic, Laura E.
Case Report: Metastatic Parosteal Osteosarcoma in a Dog
title Case Report: Metastatic Parosteal Osteosarcoma in a Dog
title_full Case Report: Metastatic Parosteal Osteosarcoma in a Dog
title_fullStr Case Report: Metastatic Parosteal Osteosarcoma in a Dog
title_full_unstemmed Case Report: Metastatic Parosteal Osteosarcoma in a Dog
title_short Case Report: Metastatic Parosteal Osteosarcoma in a Dog
title_sort case report: metastatic parosteal osteosarcoma in a dog
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421772/
https://www.ncbi.nlm.nih.gov/pubmed/34504888
http://dx.doi.org/10.3389/fvets.2021.715908
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