SARS-CoV-2 Spike Protein-Directed Monoclonal Antibodies May Ameliorate COVID-19 Complications in APECED Patients

Patients with the monogenic immune dysregulatory syndrome autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), which is caused by loss-of-function mutations in the autoimmune regulator (AIRE) gene, uniformly carry neutralizing autoantibodies directed against type-I interferons (I...

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Detalles Bibliográficos
Autores principales: Ferré, Elise M. N., Schmitt, Monica M., Ochoa, Sebastian, Rosen, Lindsey B., Shaw, Elana R., Burbelo, Peter D., Stoddard, Jennifer L., Rampertaap, Shakuntala, DiMaggio, Tom, Bergerson, Jenna R. E., Rosenzweig, Sergio D., Notarangelo, Luigi D., Holland, Steven M., Lionakis, Michail S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421855/
https://www.ncbi.nlm.nih.gov/pubmed/34504497
http://dx.doi.org/10.3389/fimmu.2021.720205

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