Cargando…
Properties improvement of titanium alloys scaffolds in bone tissue engineering: a literature review
Owing to their excellent biocompatibility and corrosion-resistant properties, titanium (Ti) (and its alloy) are essential artificial substitute biomaterials for orthopedics. However, flaws, such as weak osteogenic induction ability and higher Young’s modulus, have been observed during clinical appli...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421948/ https://www.ncbi.nlm.nih.gov/pubmed/34532396 http://dx.doi.org/10.21037/atm-20-8175 |
_version_ | 1783749183737430016 |
---|---|
author | Zuo, Weiyang Yu, Lingjia Lin, Jisheng Yang, Yong Fei, Qi |
author_facet | Zuo, Weiyang Yu, Lingjia Lin, Jisheng Yang, Yong Fei, Qi |
author_sort | Zuo, Weiyang |
collection | PubMed |
description | Owing to their excellent biocompatibility and corrosion-resistant properties, titanium (Ti) (and its alloy) are essential artificial substitute biomaterials for orthopedics. However, flaws, such as weak osteogenic induction ability and higher Young’s modulus, have been observed during clinical application. As a result, short- and long-term postoperative follow-up has found that several complications have occurred. For decades, scientists have exerted efforts to compensate for these deficiencies. Different modification methods have been investigated, including changing alloy contents, surface structure transformation, three-dimensional (3D) structure transformation, coating, and surface functionalization technologies. The cell-surface interaction effect and imitation of the natural 3D bone structure are the two main mechanisms of these improved methods. In recent years, significant progress has been made in materials science research methods, including thorough research of titanium alloys of different compositions, precise surface pattern control technology, controllable 3D structure construction technology, improvement of coating technologies, and novel concepts of surface functionalization. These improvements facilitate the possibility for further research in the field of bone tissue engineering. Although the underlying mechanism is still not fully understood, these studies still have some implications for clinical practice. Therefore, for the direction of further research, it is beneficial to summarize these studies according to the basal method used. This literature review aimed to classify these technologies, thereby providing beginners with a preliminary understanding of the field. |
format | Online Article Text |
id | pubmed-8421948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-84219482021-09-15 Properties improvement of titanium alloys scaffolds in bone tissue engineering: a literature review Zuo, Weiyang Yu, Lingjia Lin, Jisheng Yang, Yong Fei, Qi Ann Transl Med Review Article Owing to their excellent biocompatibility and corrosion-resistant properties, titanium (Ti) (and its alloy) are essential artificial substitute biomaterials for orthopedics. However, flaws, such as weak osteogenic induction ability and higher Young’s modulus, have been observed during clinical application. As a result, short- and long-term postoperative follow-up has found that several complications have occurred. For decades, scientists have exerted efforts to compensate for these deficiencies. Different modification methods have been investigated, including changing alloy contents, surface structure transformation, three-dimensional (3D) structure transformation, coating, and surface functionalization technologies. The cell-surface interaction effect and imitation of the natural 3D bone structure are the two main mechanisms of these improved methods. In recent years, significant progress has been made in materials science research methods, including thorough research of titanium alloys of different compositions, precise surface pattern control technology, controllable 3D structure construction technology, improvement of coating technologies, and novel concepts of surface functionalization. These improvements facilitate the possibility for further research in the field of bone tissue engineering. Although the underlying mechanism is still not fully understood, these studies still have some implications for clinical practice. Therefore, for the direction of further research, it is beneficial to summarize these studies according to the basal method used. This literature review aimed to classify these technologies, thereby providing beginners with a preliminary understanding of the field. AME Publishing Company 2021-08 /pmc/articles/PMC8421948/ /pubmed/34532396 http://dx.doi.org/10.21037/atm-20-8175 Text en 2021 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Review Article Zuo, Weiyang Yu, Lingjia Lin, Jisheng Yang, Yong Fei, Qi Properties improvement of titanium alloys scaffolds in bone tissue engineering: a literature review |
title | Properties improvement of titanium alloys scaffolds in bone tissue engineering: a literature review |
title_full | Properties improvement of titanium alloys scaffolds in bone tissue engineering: a literature review |
title_fullStr | Properties improvement of titanium alloys scaffolds in bone tissue engineering: a literature review |
title_full_unstemmed | Properties improvement of titanium alloys scaffolds in bone tissue engineering: a literature review |
title_short | Properties improvement of titanium alloys scaffolds in bone tissue engineering: a literature review |
title_sort | properties improvement of titanium alloys scaffolds in bone tissue engineering: a literature review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421948/ https://www.ncbi.nlm.nih.gov/pubmed/34532396 http://dx.doi.org/10.21037/atm-20-8175 |
work_keys_str_mv | AT zuoweiyang propertiesimprovementoftitaniumalloysscaffoldsinbonetissueengineeringaliteraturereview AT yulingjia propertiesimprovementoftitaniumalloysscaffoldsinbonetissueengineeringaliteraturereview AT linjisheng propertiesimprovementoftitaniumalloysscaffoldsinbonetissueengineeringaliteraturereview AT yangyong propertiesimprovementoftitaniumalloysscaffoldsinbonetissueengineeringaliteraturereview AT feiqi propertiesimprovementoftitaniumalloysscaffoldsinbonetissueengineeringaliteraturereview |