Cargando…

CXCR4 protects bone marrow-derived endothelial progenitor cells against hypoxia through the PI3K/Akt signaling pathway

The present study aimed to investigate the regulatory mechanism of chemokine (C-X-C motif) receptor 4 (CXCR4) on endothelial progenitor cells (EPCs) through the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway under hypoxic conditions. Mononuclear cells were isolated from...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Zheng-Yu, Yang, Qiu-Xia, Cao, Yan, Pan, Hong-Wei, Rong, Jing-Jing, Ling, Jing, Tang, Yi, He, Jin, Wang, Chang-Lu, Peng, Xiang, Zou, Qiong-Chao, Zhang, Le, Zheng, Jiao, Wang, Jia, Zhang, Yu, Peng, Jian-Qiang, Xiong, Lan-Bing, Liu, Feng, Ying, Zi-Hui, Zheng, Zhao-Fen, Zhang, Bai-Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422402/ https://www.ncbi.nlm.nih.gov/pubmed/34584545 http://dx.doi.org/10.3892/etm.2021.10634

Ejemplares similares

Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases
por: Wang, Qian, et al.
Publicado: (2022)

Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling
por: Zheng, Jiayi, et al.
Publicado: (2020)

Endoscopic ultrasound-guided intraportal injection of autologous bone marrow in patients with decompensated liver cirrhosis: A case series
por: Zheng, Shao-Peng, et al.
Publicado: (2023)

Endothelial progenitor cells and neural progenitor cells synergistically protect cerebral endothelial cells from Hypoxia/reoxygenation-induced injury via activating the PI3K/Akt pathway
por: Wang, Jinju, et al.
Publicado: (2016)

SDF1/CXCR4 axis facilitates the angiogenesis via activating the PI3K/AKT pathway in degenerated discs
por: Zhang, Hanxiang, et al.
Publicado: (2020)

Expression of the CXCL12/CXCR4 and CXCL16/CXCR6 axes in cervical intraepithelial neoplasia and cervical cancer
por: Huang, Yu, et al.
Publicado: (2013)

Ginsenoside Rb1 Modulates the Migration of Bone-Derived Mesenchymal Stem Cells through the SDF-1/CXCR4 Axis and PI3K/Akt Pathway
por: Liu, Yimei, et al.
Publicado: (2022)

Generation of Oligodendrocyte Progenitor Cells From Mouse Bone Marrow Cells
por: Zhang, Yuan, et al.
Publicado: (2019)

The PI3K/Akt pathway upregulates Id1 and integrin α4 to enhance recruitment of human ovarian cancer endothelial progenitor cells
por: Su, Yajuan, et al.
Publicado: (2010)

Transplantation of bone marrow-derived endothelial progenitor cells and hepatocyte stem cells from liver fibrosis rats ameliorates liver fibrosis
por: Lan, Ling, et al.
Publicado: (2018)

Protective effects of safranal on hypoxia/reoxygenation-induced injury in H9c2 cardiac myoblasts via the PI3K/AKT/GSK3β signaling pathway
por: Wang, Hefei, et al.
Publicado: (2021)

Hypoxia-induced PLOD2 promotes proliferation, migration and invasion via PI3K/Akt signaling in glioma
por: Song, Ye, et al.
Publicado: (2017)

Effect of the PI3K/AKT signaling pathway on hypoxia-induced proliferation and differentiation of bone marrow-derived mesenchymal stem cells
por: Sheng, Lingling, et al.
Publicado: (2017)

Peptide hormone ELABELA promotes rat bone marrow-derived mesenchymal stem cell proliferation and migration by manipulating the cell cycle through the PI3K/AKT pathway under the hypoxia and ischemia microenvironmemt
por: Chen, Xuxiang, et al.
Publicado: (2022)

Dihydroartemisinin attenuates autoimmune thyroiditis by inhibiting the CXCR3/PI3K/AKT/NF-κB signaling pathway
por: Liu, Huijuan, et al.
Publicado: (2017)

Extracellular vesicles derived from glioblastoma promote proliferation and migration of neural progenitor cells via PI3K-Akt pathway
por: Pan, Jiabin, et al.
Publicado: (2022)

PI3K/Akt and HIF-1 signaling pathway in hypoxia-ischemia
por: Zhang, Zhen, et al.
Publicado: (2018)

Hydrogen Repairs LPS-Induced Endothelial Progenitor Cells Injury via PI3K/AKT/eNOS Pathway
por: Mu, Qingjie, et al.
Publicado: (2022)

Glucocorticoid guides mobilization of bone marrow stem/progenitor cells via FPR and CXCR4 coupling
por: Gao, Wenting, et al.
Publicado: (2021)

Exercise Preconditioning Plays a Protective Role in Exhaustive Rats by Activating the PI3K-Akt Signaling Pathway
por: Li, Jingjing, et al.
Publicado: (2020)

SDF-1/CXCR4 Augments the Therapeutic Effect of Bone Marrow Mesenchymal Stem Cells in the Treatment of Lipopolysaccharide-Induced Liver Injury by Promoting Their Migration Through PI3K/Akt Signaling Pathway
por: Xiu, Guanghui, et al.
Publicado: (2020)

Effect of lipopolysaccharide on the characteristics of endothelial progenitor cells from bone marrow in mice
por: LI, HAO, et al.
Publicado: (2014)

Insulin-like growth factor 1 receptor-mediated cell survival in hypoxia depends on the promotion of autophagy via suppression of the PI3K/Akt/mTOR signaling pathway
por: Liu, Qi, et al.
Publicado: (2017)

TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K/AKT pathway and PPP metabolism
por: Cheng, Jie, et al.
Publicado: (2020)

IL-8 is a novel prometastatic chemokine in intrahepatic cholangiocarcinoma that induces CXCR2-PI3K/AKT signaling upon CD97 activation
por: Meng, Ze-Wu, et al.
Publicado: (2023)

Sevoflurane Postconditioning Protects Rat Hearts against Ischemia-Reperfusion Injury via the Activation of PI3K/AKT/mTOR Signaling
por: Zhang, Jing, et al.
Publicado: (2014)

Xiaotan Jieyu Prescription Alleviates Breast Precancerous Lesions through PI3K/Akt Signaling Pathway
por: Zhao, Jing, et al.
Publicado: (2020)

The Therapeutic Value of Bone Marrow-Derived Endothelial Progenitor Cell Transplantation after Intracerebral Hemorrhage in Rats
por: Zhang, Rui, et al.
Publicado: (2017)

Mesenchymal Stem Cells Attract Endothelial Progenitor Cells via a Positive Feedback Loop between CXCR2 and CXCR4
por: Tan, Yingyun, et al.
Publicado: (2019)

CXCR7 Participates in CXCL12-mediated Cell Cycle and Proliferation Regulation in Mouse Neural Progenitor Cells
por: Wang, Y., et al.
Publicado: (2016)

Expansion of Endothelial Progenitor Cells in High Density Dot Culture of Rat Bone Marrow Cells
por: Lu, Yang, et al.
Publicado: (2014)

Icariin inhibits oral squamous cell carcinoma cell proliferation and induces apoptosis via inhibiting the NF-κB and PI3K/AKT pathways
por: Sun, Ling, et al.
Publicado: (2021)

Hypoxia-Activated PI3K/Akt Inhibits Oxidative Stress via the Regulation of Reactive Oxygen Species in Human Dental Pulp Cells
por: Liu, Fei, et al.
Publicado: (2019)

Upregulation of GLT-1 via PI3K/Akt Pathway Contributes to Neuroprotection Induced by Dexmedetomidine
por: Peng, Mengyuan, et al.
Publicado: (2019)

Exosome miR-371b-5p promotes proliferation of lung alveolar progenitor type II cells by using PTEN to orchestrate the PI3K/Akt signaling
por: Quan, Yuan, et al.
Publicado: (2017)

CXCR4 blockade sensitizes osteosarcoma to doxorubicin by inducing autophagic cell death via PI3K-Akt-mTOR pathway inhibition
por: Liao, Yu-Xin, et al.
Publicado: (2021)

Correlation of CXCR4/CXCR7 signaling pathway with pre-eclampsia
por: Zheng, Zhi, et al.
Publicado: (2018)

Investigating the causal effect of Dickkopf-1 on coronary artery disease and ischemic stroke: a Mendelian randomization study
por: Zheng, Peng-Fei, et al.
Publicado: (2023)

CXCR1/CXCR2 Antagonism Is Effective in Pulmonary Defense against Klebsiella pneumoniae Infection
por: Wei, Jing, et al.
Publicado: (2013)

Anti-Glioma Effects of Ligustilide or n-Butylphthalide on Their Own and the Synergistic Effects with Temozolomide via PI3K/Akt Signaling Pathway
por: Li, Zi-Qi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_r9pi16ga6lsgo187umd0mf090b