An altered heparan sulfate structure in the articular cartilage protects against osteoarthritis

OBJECTIVE: Osteoarthritis (OA) is a progressive degenerative disease of the articular cartilage caused by an unbalanced activity of proteases, cytokines and other secreted proteins. Since heparan sulfate (HS) determines the activity of many extracellular factors, we investigated its role in OA progr...

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Detalles Bibliográficos
Autores principales: Severmann, A.-C., Jochmann, K., Feller, K., Bachvarova, V., Piombo, V., Stange, R., Holzer, T., Brachvogel, B., Esko, J., Pap, T., Hoffmann, D., Vortkamp, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422443/
https://www.ncbi.nlm.nih.gov/pubmed/32315715
http://dx.doi.org/10.1016/j.joca.2020.04.002

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