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Impact of early life nutrition on gut health in children: a prospective clinical study

INTRODUCTION: The first 1000 days of life could contribute to individual susceptibility to the later development of chronic non-communicable diseases. Nutrition in early life appears to be an important determinant factor for a sustainable child’s health. In this study, we propose to investigate the...

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Autores principales: Ley, Delphine, Beghin, Laurent, Morcel, Jules, Flamein, Florence, Garabedian, Charles, Accart, Bertrand, Drumez, Elodie, Labreuche, Julien, Gottrand, Frederic, Hermann, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422494/
https://www.ncbi.nlm.nih.gov/pubmed/34489289
http://dx.doi.org/10.1136/bmjopen-2021-050432
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author Ley, Delphine
Beghin, Laurent
Morcel, Jules
Flamein, Florence
Garabedian, Charles
Accart, Bertrand
Drumez, Elodie
Labreuche, Julien
Gottrand, Frederic
Hermann, Emmanuel
author_facet Ley, Delphine
Beghin, Laurent
Morcel, Jules
Flamein, Florence
Garabedian, Charles
Accart, Bertrand
Drumez, Elodie
Labreuche, Julien
Gottrand, Frederic
Hermann, Emmanuel
author_sort Ley, Delphine
collection PubMed
description INTRODUCTION: The first 1000 days of life could contribute to individual susceptibility to the later development of chronic non-communicable diseases. Nutrition in early life appears to be an important determinant factor for a sustainable child’s health. In this study, we propose to investigate the impact of exclusive breast feeding on gut health in children. METHODS AND ANALYSIS: A prospective cohort of newborns (n=350) will be recruited at birth and followed up to 4 years of age. The main objective is to evaluate the link between exclusive breast feeding for at least 3 months and the gut health of the child at 4 years. The primary endpoint of assessment of gut health will be based on the non-invasive measurement of faecal secretory IgA (sIgA) as a sensitive biomarker of the intestinal ecosystem. The presence of gastrointestinal disorders will be defined according to the clinical criteria of Rome IV. Information on parent’s nutritional habits and life style, breastfeeding duration and child’s complementary feeding will be collected along the follow-up. Cord blood cells and plasma at birth will be purified for further analysis. The meconium and stools collected at birth, 6 months, 2 years and 4 years of age will allow sIgA analysis. ETHICS AND DISSEMINATION: This clinical study has obtained the approval from the national ethical committee. We plan to publish the results of the study in peer-review journals and by means of national and international conference. TRIAL REGISTRATION NUMBER: NCT04195425.
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spelling pubmed-84224942021-09-22 Impact of early life nutrition on gut health in children: a prospective clinical study Ley, Delphine Beghin, Laurent Morcel, Jules Flamein, Florence Garabedian, Charles Accart, Bertrand Drumez, Elodie Labreuche, Julien Gottrand, Frederic Hermann, Emmanuel BMJ Open Gastroenterology and Hepatology INTRODUCTION: The first 1000 days of life could contribute to individual susceptibility to the later development of chronic non-communicable diseases. Nutrition in early life appears to be an important determinant factor for a sustainable child’s health. In this study, we propose to investigate the impact of exclusive breast feeding on gut health in children. METHODS AND ANALYSIS: A prospective cohort of newborns (n=350) will be recruited at birth and followed up to 4 years of age. The main objective is to evaluate the link between exclusive breast feeding for at least 3 months and the gut health of the child at 4 years. The primary endpoint of assessment of gut health will be based on the non-invasive measurement of faecal secretory IgA (sIgA) as a sensitive biomarker of the intestinal ecosystem. The presence of gastrointestinal disorders will be defined according to the clinical criteria of Rome IV. Information on parent’s nutritional habits and life style, breastfeeding duration and child’s complementary feeding will be collected along the follow-up. Cord blood cells and plasma at birth will be purified for further analysis. The meconium and stools collected at birth, 6 months, 2 years and 4 years of age will allow sIgA analysis. ETHICS AND DISSEMINATION: This clinical study has obtained the approval from the national ethical committee. We plan to publish the results of the study in peer-review journals and by means of national and international conference. TRIAL REGISTRATION NUMBER: NCT04195425. BMJ Publishing Group 2021-09-06 /pmc/articles/PMC8422494/ /pubmed/34489289 http://dx.doi.org/10.1136/bmjopen-2021-050432 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Gastroenterology and Hepatology
Ley, Delphine
Beghin, Laurent
Morcel, Jules
Flamein, Florence
Garabedian, Charles
Accart, Bertrand
Drumez, Elodie
Labreuche, Julien
Gottrand, Frederic
Hermann, Emmanuel
Impact of early life nutrition on gut health in children: a prospective clinical study
title Impact of early life nutrition on gut health in children: a prospective clinical study
title_full Impact of early life nutrition on gut health in children: a prospective clinical study
title_fullStr Impact of early life nutrition on gut health in children: a prospective clinical study
title_full_unstemmed Impact of early life nutrition on gut health in children: a prospective clinical study
title_short Impact of early life nutrition on gut health in children: a prospective clinical study
title_sort impact of early life nutrition on gut health in children: a prospective clinical study
topic Gastroenterology and Hepatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422494/
https://www.ncbi.nlm.nih.gov/pubmed/34489289
http://dx.doi.org/10.1136/bmjopen-2021-050432
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