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The potential value of plasma receptor interacting protein 3 in neonates with culture-positive late-onset sepsis
BACKGROUND: Late-onset sepsis (LOS) is a systemic inflammatory response syndrome in neonates, and the molecular mechanism of LOS is incompletely characterized. The purpose of this study was to explore the potential value of receptor interacting protein 3 (RIP3) in LOS. METHODS: 63 neonates with LOS...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422743/ https://www.ncbi.nlm.nih.gov/pubmed/34488677 http://dx.doi.org/10.1186/s12879-021-06636-0 |
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author | Gao, Chuchu Feng, Zongtai Wang, Lixia Zhao, Xingxing Fu, Kai Ma, Shurong Yang, Zuming Wang, Sannan Yu, Shenglin |
author_facet | Gao, Chuchu Feng, Zongtai Wang, Lixia Zhao, Xingxing Fu, Kai Ma, Shurong Yang, Zuming Wang, Sannan Yu, Shenglin |
author_sort | Gao, Chuchu |
collection | PubMed |
description | BACKGROUND: Late-onset sepsis (LOS) is a systemic inflammatory response syndrome in neonates, and the molecular mechanism of LOS is incompletely characterized. The purpose of this study was to explore the potential value of receptor interacting protein 3 (RIP3) in LOS. METHODS: 63 neonates with LOS supported by positive culture and 79 neonates without sepsis were enrolled in this study from September 2019 to March 2021. Plasma RIP3 was detected by enzyme-linked immunosorbent assay (ELISA) and assessed along with the whole blood hypersensitive C-reactive protein (hs-CRP) level and platelet count (PLT). Differences in RIP3, hs-CRP and PLT between the two groups were compared. Changes in the three indicators in sepsis were also observed after treatment. The diagnostic value of indicators for LOS was evaluated by receiver operating characteristic (ROC) curve analysis. RESULTS: In the sepsis group, RIP3 and hs-CRP levels were significantly higher than those in the control group (RIP3, p < 0.0001; hs-CRP, p < 0.0001), and PLT was significantly lower than that in the control group (p < 0.0001). After treatment, RIP3 and hs-CRP levels among septic survivors were significantly decreased (p < 0.0001) and PLT significantly improved (p = 0.0216). With RIP3 > 15,845.19 pg/mL, hs-CRP > 5.00 mg/L, and PLT < 204.00 × 10(9)/L as the positive criteria, the sensitivity values of the three indicators in the diagnosis of LOS were 69.8%, 60.3%, 60.3%, respectively, and the specificity values were 92.4%, 96.2%, 79.8%, respectively. The combination of RIP3, hs-CRP and PLT had a sensitivity of 77.8% and specificity of 97.5%. CONCLUSIONS: RIP3 may contribute to the early diagnosis of LOS and monitoring of treatment effect. The combined detection of RIP3, hs-CRP and PLT may be more effective than individual detection in the diagnosis of LOS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-021-06636-0. |
format | Online Article Text |
id | pubmed-8422743 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-84227432021-09-09 The potential value of plasma receptor interacting protein 3 in neonates with culture-positive late-onset sepsis Gao, Chuchu Feng, Zongtai Wang, Lixia Zhao, Xingxing Fu, Kai Ma, Shurong Yang, Zuming Wang, Sannan Yu, Shenglin BMC Infect Dis Research BACKGROUND: Late-onset sepsis (LOS) is a systemic inflammatory response syndrome in neonates, and the molecular mechanism of LOS is incompletely characterized. The purpose of this study was to explore the potential value of receptor interacting protein 3 (RIP3) in LOS. METHODS: 63 neonates with LOS supported by positive culture and 79 neonates without sepsis were enrolled in this study from September 2019 to March 2021. Plasma RIP3 was detected by enzyme-linked immunosorbent assay (ELISA) and assessed along with the whole blood hypersensitive C-reactive protein (hs-CRP) level and platelet count (PLT). Differences in RIP3, hs-CRP and PLT between the two groups were compared. Changes in the three indicators in sepsis were also observed after treatment. The diagnostic value of indicators for LOS was evaluated by receiver operating characteristic (ROC) curve analysis. RESULTS: In the sepsis group, RIP3 and hs-CRP levels were significantly higher than those in the control group (RIP3, p < 0.0001; hs-CRP, p < 0.0001), and PLT was significantly lower than that in the control group (p < 0.0001). After treatment, RIP3 and hs-CRP levels among septic survivors were significantly decreased (p < 0.0001) and PLT significantly improved (p = 0.0216). With RIP3 > 15,845.19 pg/mL, hs-CRP > 5.00 mg/L, and PLT < 204.00 × 10(9)/L as the positive criteria, the sensitivity values of the three indicators in the diagnosis of LOS were 69.8%, 60.3%, 60.3%, respectively, and the specificity values were 92.4%, 96.2%, 79.8%, respectively. The combination of RIP3, hs-CRP and PLT had a sensitivity of 77.8% and specificity of 97.5%. CONCLUSIONS: RIP3 may contribute to the early diagnosis of LOS and monitoring of treatment effect. The combined detection of RIP3, hs-CRP and PLT may be more effective than individual detection in the diagnosis of LOS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-021-06636-0. BioMed Central 2021-09-06 /pmc/articles/PMC8422743/ /pubmed/34488677 http://dx.doi.org/10.1186/s12879-021-06636-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Gao, Chuchu Feng, Zongtai Wang, Lixia Zhao, Xingxing Fu, Kai Ma, Shurong Yang, Zuming Wang, Sannan Yu, Shenglin The potential value of plasma receptor interacting protein 3 in neonates with culture-positive late-onset sepsis |
title | The potential value of plasma receptor interacting protein 3 in neonates with culture-positive late-onset sepsis |
title_full | The potential value of plasma receptor interacting protein 3 in neonates with culture-positive late-onset sepsis |
title_fullStr | The potential value of plasma receptor interacting protein 3 in neonates with culture-positive late-onset sepsis |
title_full_unstemmed | The potential value of plasma receptor interacting protein 3 in neonates with culture-positive late-onset sepsis |
title_short | The potential value of plasma receptor interacting protein 3 in neonates with culture-positive late-onset sepsis |
title_sort | potential value of plasma receptor interacting protein 3 in neonates with culture-positive late-onset sepsis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422743/ https://www.ncbi.nlm.nih.gov/pubmed/34488677 http://dx.doi.org/10.1186/s12879-021-06636-0 |
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