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Altered trigeminothalamic spontaneous low-frequency oscillations in migraine without aura: a resting-state fMRI study
BACKGROUND: Recent resting-state fMRI studies demonstrated functional dysconnectivity within the central pain matrix in migraineurs. This study aimed to investigate the spatial distribution and amplitude of low-frequency oscillations (LFOs) using fractional amplitude of low-frequency fluctuation (fA...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422747/ https://www.ncbi.nlm.nih.gov/pubmed/34493235 http://dx.doi.org/10.1186/s12883-021-02374-7 |
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author | Kim, Ye Eun Kim, Min Kyung Suh, Sang-il Kim, Ji Hyun |
author_facet | Kim, Ye Eun Kim, Min Kyung Suh, Sang-il Kim, Ji Hyun |
author_sort | Kim, Ye Eun |
collection | PubMed |
description | BACKGROUND: Recent resting-state fMRI studies demonstrated functional dysconnectivity within the central pain matrix in migraineurs. This study aimed to investigate the spatial distribution and amplitude of low-frequency oscillations (LFOs) using fractional amplitude of low-frequency fluctuation (fALFF) analysis in migraine patients without aura, and to examine relationships between regional LFOs and clinical variables. METHODS: Resting-state fMRI data were obtained and preprocessed in 44 migraine patients without aura and 31 matched controls. fALFF was computed according to the original method, z-transformed for standardization, and compared between migraineurs and controls. Correlation analysis between regional fALFF and clinical variables was performed in migraineurs as well. RESULTS: Compared with controls, migraineurs had significant fALFF increases in bilateral ventral posteromedial (VPM) thalamus and brainstem encompassing rostral ventromedial medulla (RVM) and trigeminocervical complex (TCC). Regional fALFF values of bilateral VPM thalamus and brainstem positively correlated with disease duration, but not with migraine attack frequency or Migraine Disability Assessment Scale score. CONCLUSIONS: We have provided evidence for abnormal LFOs in the brainstem including RVM/TCC and thalamic VPM nucleus in migraine without aura, implicating trigeminothalamic network oscillations in migraine pathophysiology. Our results suggest that enhanced LFO activity may underpin the interictal trigeminothalamic dysrhythmia that could contribute to the impairments of pain transmission and modulation in migraine. Given our finding of increasing fALFF in relation to increasing disease duration, the observed trigeminothalamic dysrhythmia may indicate either an inherent pathology leading to migraine headaches or a consequence of repeated attacks on the brain. |
format | Online Article Text |
id | pubmed-8422747 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-84227472021-09-09 Altered trigeminothalamic spontaneous low-frequency oscillations in migraine without aura: a resting-state fMRI study Kim, Ye Eun Kim, Min Kyung Suh, Sang-il Kim, Ji Hyun BMC Neurol Research BACKGROUND: Recent resting-state fMRI studies demonstrated functional dysconnectivity within the central pain matrix in migraineurs. This study aimed to investigate the spatial distribution and amplitude of low-frequency oscillations (LFOs) using fractional amplitude of low-frequency fluctuation (fALFF) analysis in migraine patients without aura, and to examine relationships between regional LFOs and clinical variables. METHODS: Resting-state fMRI data were obtained and preprocessed in 44 migraine patients without aura and 31 matched controls. fALFF was computed according to the original method, z-transformed for standardization, and compared between migraineurs and controls. Correlation analysis between regional fALFF and clinical variables was performed in migraineurs as well. RESULTS: Compared with controls, migraineurs had significant fALFF increases in bilateral ventral posteromedial (VPM) thalamus and brainstem encompassing rostral ventromedial medulla (RVM) and trigeminocervical complex (TCC). Regional fALFF values of bilateral VPM thalamus and brainstem positively correlated with disease duration, but not with migraine attack frequency or Migraine Disability Assessment Scale score. CONCLUSIONS: We have provided evidence for abnormal LFOs in the brainstem including RVM/TCC and thalamic VPM nucleus in migraine without aura, implicating trigeminothalamic network oscillations in migraine pathophysiology. Our results suggest that enhanced LFO activity may underpin the interictal trigeminothalamic dysrhythmia that could contribute to the impairments of pain transmission and modulation in migraine. Given our finding of increasing fALFF in relation to increasing disease duration, the observed trigeminothalamic dysrhythmia may indicate either an inherent pathology leading to migraine headaches or a consequence of repeated attacks on the brain. BioMed Central 2021-09-07 /pmc/articles/PMC8422747/ /pubmed/34493235 http://dx.doi.org/10.1186/s12883-021-02374-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Kim, Ye Eun Kim, Min Kyung Suh, Sang-il Kim, Ji Hyun Altered trigeminothalamic spontaneous low-frequency oscillations in migraine without aura: a resting-state fMRI study |
title | Altered trigeminothalamic spontaneous low-frequency oscillations in migraine without aura: a resting-state fMRI study |
title_full | Altered trigeminothalamic spontaneous low-frequency oscillations in migraine without aura: a resting-state fMRI study |
title_fullStr | Altered trigeminothalamic spontaneous low-frequency oscillations in migraine without aura: a resting-state fMRI study |
title_full_unstemmed | Altered trigeminothalamic spontaneous low-frequency oscillations in migraine without aura: a resting-state fMRI study |
title_short | Altered trigeminothalamic spontaneous low-frequency oscillations in migraine without aura: a resting-state fMRI study |
title_sort | altered trigeminothalamic spontaneous low-frequency oscillations in migraine without aura: a resting-state fmri study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422747/ https://www.ncbi.nlm.nih.gov/pubmed/34493235 http://dx.doi.org/10.1186/s12883-021-02374-7 |
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