Circulating Cell-Free DNA-Based Detection of Tumor Suppressor Gene Copy Number Loss and Its Clinical Implication in Metastatic Prostate Cancer

Current liquid biopsy assays lack sufficient sensitivity to detect copy number loss, which limits the interrogation of critical tumor suppressor gene deletions during cancer progression and treatment. Here we describe a liquid biopsy assay with improved sensitivity for detection of copy number loss...

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Detalles Bibliográficos
Autores principales: Dong, Xiaoxi, Zheng, Tiantian, Zhang, Minhua, Dai, Chao, Wang, Lili, Wang, Lei, Zhang, Ruipeng, Long, Yuan, Wen, Danyi, Xie, Feng, Zhang, Yue, Huang, Yong, Dong, Jianguo, Liu, Huan, Du, Pan, King, Bonnie L., Tan, Winston, Jia, Shidong, Lu, Chris X., Kohli, Manish, Wang, Haitao, Yu, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422845/
https://www.ncbi.nlm.nih.gov/pubmed/34504797
http://dx.doi.org/10.3389/fonc.2021.720727
Descripción
Sumario:Current liquid biopsy assays lack sufficient sensitivity to detect copy number loss, which limits the interrogation of critical tumor suppressor gene deletions during cancer progression and treatment. Here we describe a liquid biopsy assay with improved sensitivity for detection of copy number loss in blood samples with low levels of circulating tumor DNA, and demonstrate its utility by profiling PTEN, RB1, and TP53 genetic loss in metastatic prostate cancer patients.

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