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Circulating Cell-Free DNA-Based Detection of Tumor Suppressor Gene Copy Number Loss and Its Clinical Implication in Metastatic Prostate Cancer
Current liquid biopsy assays lack sufficient sensitivity to detect copy number loss, which limits the interrogation of critical tumor suppressor gene deletions during cancer progression and treatment. Here we describe a liquid biopsy assay with improved sensitivity for detection of copy number loss...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422845/ https://www.ncbi.nlm.nih.gov/pubmed/34504797 http://dx.doi.org/10.3389/fonc.2021.720727 |
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| author | Dong, Xiaoxi Zheng, Tiantian Zhang, Minhua Dai, Chao Wang, Lili Wang, Lei Zhang, Ruipeng Long, Yuan Wen, Danyi Xie, Feng Zhang, Yue Huang, Yong Dong, Jianguo Liu, Huan Du, Pan King, Bonnie L. Tan, Winston Jia, Shidong Lu, Chris X. Kohli, Manish Wang, Haitao Yu, Jianjun |
| author_facet | Dong, Xiaoxi Zheng, Tiantian Zhang, Minhua Dai, Chao Wang, Lili Wang, Lei Zhang, Ruipeng Long, Yuan Wen, Danyi Xie, Feng Zhang, Yue Huang, Yong Dong, Jianguo Liu, Huan Du, Pan King, Bonnie L. Tan, Winston Jia, Shidong Lu, Chris X. Kohli, Manish Wang, Haitao Yu, Jianjun |
| author_sort | Dong, Xiaoxi |
| collection | PubMed |
| description | Current liquid biopsy assays lack sufficient sensitivity to detect copy number loss, which limits the interrogation of critical tumor suppressor gene deletions during cancer progression and treatment. Here we describe a liquid biopsy assay with improved sensitivity for detection of copy number loss in blood samples with low levels of circulating tumor DNA, and demonstrate its utility by profiling PTEN, RB1, and TP53 genetic loss in metastatic prostate cancer patients. |
| format | Online Article Text |
| id | pubmed-8422845 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-84228452021-09-08 Circulating Cell-Free DNA-Based Detection of Tumor Suppressor Gene Copy Number Loss and Its Clinical Implication in Metastatic Prostate Cancer Dong, Xiaoxi Zheng, Tiantian Zhang, Minhua Dai, Chao Wang, Lili Wang, Lei Zhang, Ruipeng Long, Yuan Wen, Danyi Xie, Feng Zhang, Yue Huang, Yong Dong, Jianguo Liu, Huan Du, Pan King, Bonnie L. Tan, Winston Jia, Shidong Lu, Chris X. Kohli, Manish Wang, Haitao Yu, Jianjun Front Oncol Oncology Current liquid biopsy assays lack sufficient sensitivity to detect copy number loss, which limits the interrogation of critical tumor suppressor gene deletions during cancer progression and treatment. Here we describe a liquid biopsy assay with improved sensitivity for detection of copy number loss in blood samples with low levels of circulating tumor DNA, and demonstrate its utility by profiling PTEN, RB1, and TP53 genetic loss in metastatic prostate cancer patients. Frontiers Media S.A. 2021-08-24 /pmc/articles/PMC8422845/ /pubmed/34504797 http://dx.doi.org/10.3389/fonc.2021.720727 Text en Copyright © 2021 Dong, Zheng, Zhang, Dai, Wang, Wang, Zhang, Long, Wen, Xie, Zhang, Huang, Dong, Liu, Du, King, Tan, Jia, Lu, Kohli, Wang and Yu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Oncology Dong, Xiaoxi Zheng, Tiantian Zhang, Minhua Dai, Chao Wang, Lili Wang, Lei Zhang, Ruipeng Long, Yuan Wen, Danyi Xie, Feng Zhang, Yue Huang, Yong Dong, Jianguo Liu, Huan Du, Pan King, Bonnie L. Tan, Winston Jia, Shidong Lu, Chris X. Kohli, Manish Wang, Haitao Yu, Jianjun Circulating Cell-Free DNA-Based Detection of Tumor Suppressor Gene Copy Number Loss and Its Clinical Implication in Metastatic Prostate Cancer |
| title | Circulating Cell-Free DNA-Based Detection of Tumor Suppressor Gene Copy Number Loss and Its Clinical Implication in Metastatic Prostate Cancer |
| title_full | Circulating Cell-Free DNA-Based Detection of Tumor Suppressor Gene Copy Number Loss and Its Clinical Implication in Metastatic Prostate Cancer |
| title_fullStr | Circulating Cell-Free DNA-Based Detection of Tumor Suppressor Gene Copy Number Loss and Its Clinical Implication in Metastatic Prostate Cancer |
| title_full_unstemmed | Circulating Cell-Free DNA-Based Detection of Tumor Suppressor Gene Copy Number Loss and Its Clinical Implication in Metastatic Prostate Cancer |
| title_short | Circulating Cell-Free DNA-Based Detection of Tumor Suppressor Gene Copy Number Loss and Its Clinical Implication in Metastatic Prostate Cancer |
| title_sort | circulating cell-free dna-based detection of tumor suppressor gene copy number loss and its clinical implication in metastatic prostate cancer |
| topic | Oncology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422845/ https://www.ncbi.nlm.nih.gov/pubmed/34504797 http://dx.doi.org/10.3389/fonc.2021.720727 |
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