A Novel Oral Arginase 1/2 Inhibitor Enhances the Antitumor Effect of PD-1 Inhibition in Murine Experimental Gliomas by Altering the Immunosuppressive Environment

Glioblastomas (GBM) are the common and aggressive primary brain tumors that are incurable by conventional therapies. Immunotherapy with immune checkpoint inhibitors is not effective in GBM patients due to the highly immunosuppressive tumor microenvironment (TME) restraining the infiltration and acti...

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Detalles Bibliográficos
Autores principales: Pilanc, Paulina, Wojnicki, Kamil, Roura, Adria-Jaume, Cyranowski, Salwador, Ellert-Miklaszewska, Aleksandra, Ochocka, Natalia, Gielniewski, Bartłomiej, Grzybowski, Marcin M., Błaszczyk, Roman, Stańczak, Paulina S., Dobrzański, Paweł, Kaminska, Bozena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422859/
https://www.ncbi.nlm.nih.gov/pubmed/34504786
http://dx.doi.org/10.3389/fonc.2021.703465

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