A primer on metabolic memory: why existing diabesity treatments fail

Despite massive government and private sector investments into prevention of cardiovascular disease, diabetes mellitus and obesity, efforts have largely failed, and the burden of cost remains in the treatment of downstream morbidity and mortality, with overall stagnating outcomes. A new paradigm shi...

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Detalles Bibliográficos
Autores principales: Copur, Sidar, Rossing, Peter, Afsar, Baris, Sag, Alan A, Siriopol, Dimitrie, Kuwabara, Masanari, Ortiz, Alberto, Kanbay, Mehmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
CKJ Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422888/
https://www.ncbi.nlm.nih.gov/pubmed/34512957
http://dx.doi.org/10.1093/ckj/sfaa143
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author Copur, Sidar
Rossing, Peter
Afsar, Baris
Sag, Alan A
Siriopol, Dimitrie
Kuwabara, Masanari
Ortiz, Alberto
Kanbay, Mehmet
author_facet Copur, Sidar
Rossing, Peter
Afsar, Baris
Sag, Alan A
Siriopol, Dimitrie
Kuwabara, Masanari
Ortiz, Alberto
Kanbay, Mehmet
author_sort Copur, Sidar
collection PubMed
description Despite massive government and private sector investments into prevention of cardiovascular disease, diabetes mellitus and obesity, efforts have largely failed, and the burden of cost remains in the treatment of downstream morbidity and mortality, with overall stagnating outcomes. A new paradigm shift in the approach to these patients may explain why existing treatment strategies fail, and offer new treatment targets. This review aims to provide a clinician-centred primer on metabolic memory, defined as the sum of irreversible genetic, epigenetic, cellular and tissue-level alterations that occur with long-time exposure to metabolic derangements.
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spelling pubmed-84228882021-09-09 A primer on metabolic memory: why existing diabesity treatments fail Copur, Sidar Rossing, Peter Afsar, Baris Sag, Alan A Siriopol, Dimitrie Kuwabara, Masanari Ortiz, Alberto Kanbay, Mehmet Clin Kidney J CKJ Reviews Despite massive government and private sector investments into prevention of cardiovascular disease, diabetes mellitus and obesity, efforts have largely failed, and the burden of cost remains in the treatment of downstream morbidity and mortality, with overall stagnating outcomes. A new paradigm shift in the approach to these patients may explain why existing treatment strategies fail, and offer new treatment targets. This review aims to provide a clinician-centred primer on metabolic memory, defined as the sum of irreversible genetic, epigenetic, cellular and tissue-level alterations that occur with long-time exposure to metabolic derangements. Oxford University Press 2020-09-02 /pmc/articles/PMC8422888/ /pubmed/34512957 http://dx.doi.org/10.1093/ckj/sfaa143 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle CKJ Reviews
Copur, Sidar
Rossing, Peter
Afsar, Baris
Sag, Alan A
Siriopol, Dimitrie
Kuwabara, Masanari
Ortiz, Alberto
Kanbay, Mehmet
A primer on metabolic memory: why existing diabesity treatments fail
title A primer on metabolic memory: why existing diabesity treatments fail
title_full A primer on metabolic memory: why existing diabesity treatments fail
title_fullStr A primer on metabolic memory: why existing diabesity treatments fail
title_full_unstemmed A primer on metabolic memory: why existing diabesity treatments fail
title_short A primer on metabolic memory: why existing diabesity treatments fail
title_sort primer on metabolic memory: why existing diabesity treatments fail
topic CKJ Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422888/
https://www.ncbi.nlm.nih.gov/pubmed/34512957
http://dx.doi.org/10.1093/ckj/sfaa143
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