Regulators of liver cancer stem cells

Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths. It is often detected at a stage when there are few therapeutic options. Liver cancer stem cells (LCSCs) are highly tumorigenic and resistant to chemotherapy and radiation therapy. Their presence in HCC is a major reason why HCC is d...

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Detalles Bibliográficos
Autores principales: Liu, Kai, Ou, Jing-Hsiung James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422929/
https://www.ncbi.nlm.nih.gov/pubmed/34567430
http://dx.doi.org/10.4252/wjsc.v13.i8.1127
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author Liu, Kai
Ou, Jing-Hsiung James
author_facet Liu, Kai
Ou, Jing-Hsiung James
author_sort Liu, Kai
collection PubMed
description Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths. It is often detected at a stage when there are few therapeutic options. Liver cancer stem cells (LCSCs) are highly tumorigenic and resistant to chemotherapy and radiation therapy. Their presence in HCC is a major reason why HCC is difficult to treat. The development of LCSCs is regulated by a variety of factors. This review summarizes recent advances on the factors that regulate the development of LCSCs. Due to the importance of LCSCs in the development of HCC, a better understanding of how LCSCs are regulated will help to improve the treatments for HCC patients.
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spelling pubmed-84229292021-09-24 Regulators of liver cancer stem cells Liu, Kai Ou, Jing-Hsiung James World J Stem Cells Minireviews Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths. It is often detected at a stage when there are few therapeutic options. Liver cancer stem cells (LCSCs) are highly tumorigenic and resistant to chemotherapy and radiation therapy. Their presence in HCC is a major reason why HCC is difficult to treat. The development of LCSCs is regulated by a variety of factors. This review summarizes recent advances on the factors that regulate the development of LCSCs. Due to the importance of LCSCs in the development of HCC, a better understanding of how LCSCs are regulated will help to improve the treatments for HCC patients. Baishideng Publishing Group Inc 2021-08-26 2021-08-26 /pmc/articles/PMC8422929/ /pubmed/34567430 http://dx.doi.org/10.4252/wjsc.v13.i8.1127 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Minireviews
Liu, Kai
Ou, Jing-Hsiung James
Regulators of liver cancer stem cells
title Regulators of liver cancer stem cells
title_full Regulators of liver cancer stem cells
title_fullStr Regulators of liver cancer stem cells
title_full_unstemmed Regulators of liver cancer stem cells
title_short Regulators of liver cancer stem cells
title_sort regulators of liver cancer stem cells
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422929/
https://www.ncbi.nlm.nih.gov/pubmed/34567430
http://dx.doi.org/10.4252/wjsc.v13.i8.1127
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