Cargando…

Down-regulation of IGHG1 enhances Protoporphyrin IX accumulation and inhibits hemin biosynthesis in colorectal cancer by suppressing the MEK-FECH axis

Immunoglobulin γ-1 heavy chain constant region (IGHG1) is a functional isoform of immunoglobulins and plays an important role in the cytolytic activity of immune effector cells. Dysregulated IGHG1 was implicated in the occurrence and development of various tumors. Protoporphyrin IX (PpIX) is an endo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Guangjian, Li, Gang, Du, Xuemei, Zhou, Wenting, Zou, Xiaohong, Liu, Yuanfu, Lv, Hong, Li, Zhenjiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	De Gruyter 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422984/ https://www.ncbi.nlm.nih.gov/pubmed/34553073 http://dx.doi.org/10.1515/biol-2021-0098

Ejemplares similares

MEK reduces cancer-specific PpIX accumulation through the RSK-ABCB1 and HIF-1α-FECH axes
por: Chelakkot, Vipin Shankar, et al.
Publicado: (2020)

Hemin and Zinc Protoporphyrin IX Affect Granisetron Constipating Effects In Vitro and In Vivo
por: Zigrino, Addolorata, et al.
Publicado: (2013)

Enhancement of Cancer-Specific Protoporphyrin IX Fluorescence by Targeting Oncogenic Ras/MEK Pathway
por: Yoshioka, Ema, et al.
Publicado: (2018)

Chlorophyll-deficient mutants of Chlamydomonas reinhardtii that accumulate magnesium protoporphyrin IX
por: Meinecke, Linda, et al.
Publicado: (2010)

Quantification of Protoporphyrin IX Accumulation in Glioblastoma Cells: A New Technique
por: Lawrence, Johnathan E., et al.
Publicado: (2014)

BIMG-17. EFFECTS OF THE TUMOUR MICROENVIRONMENT ON PROTOPORPHYRIN IX ACCUMULATION IN GLIOBLASTOMA
por: Walker, Paul, et al.
Publicado: (2021)

Oxygen Availability for Porphyrin Biosynthesis Enzymes Determines the Production of Protoporphyrin IX (PpIX) during Hypoxia
por: Otsuka, Shimpei, et al.
Publicado: (2015)

GENETIC CONTROL OF CHLOROPHYLL BIOSYNTHESIS IN CHLAMYDOMONAS : Analysis of Mutants at Two Loci Mediating the Conversion of Protoporphyrin-IX to Magnesium Protoporphyrin
por: Wang, Wei-Yeh, et al.
Publicado: (1974)

IGHG1 Regulates Prostate Cancer Growth via the MEK/ERK/c-Myc Pathway
por: Chu, Jing, et al.
Publicado: (2019)

Simultaneous determination of protoporphyrin IX and magnesium protoporphyrin IX in Arabidopsis thaliana and Camellia sinensis using UPLC-MS/MS
por: Zhang, Chenyu, et al.
Publicado: (2023)

Co-protoporphyrin IX and Sn-protoporphyrin IX inactivate Zika, Chikungunya and other arboviruses by targeting the viral envelope
por: Neris, Romulo L. S., et al.
Publicado: (2018)

Reddish Colour in Cooked Ham Is Developed by a Mixture of Protoporphyrins Including Zn-Protoporphyrin and Protoporphyrin IX
por: Giménez-Campillo, Claudia, et al.
Publicado: (2022)

Brazilian Green Propolis Extract Synergizes with Protoporphyrin IX-mediated Photodynamic Therapy via Enhancement of Intracellular Accumulation of Protoporphyrin IX and Attenuation of NF-κB and COX-2
por: Wang, Cheng-Cheng, et al.
Publicado: (2017)

The influence of iron chelators on the accumulation of protoporphyrin IX in 5-aminolaevulinic acid-treated cells.
por: Berg, K., et al.
Publicado: (1996)

Differentiation-specific increase in ALA-induced protoporphyrin IX accumulation in primary mouse keratinocytes.
por: Ortel, B., et al.
Publicado: (1998)

Photodynamic action of protoporphyrin IX derivatives on Trichophyton rubrum
por: Ramos, Rogério Rodrigo, et al.
Publicado: (2016)

Binding of Immunoglobulin G to Protoporphyrin IX and Its Derivatives: Evidence the Fab Domain Recognizes the Protoporphyrin Ring
por: Orino, Koichi
Publicado: (2019)

Mg-Protoporphyrin IX Signals Enhance Plant’s Tolerance to Cold Stress
por: Zhang, Zhong-Wei, et al.
Publicado: (2016)

Factors affecting aminolaevulinic acid-induced generation of protoporphyrin IX.
por: Wyld, L., et al.
Publicado: (1997)

Characterization and standardization of tissue-simulating protoporphyrin IX optical phantoms
por: Marois, Mikael, et al.
Publicado: (2016)

Design and synthesis of a 4-aminoquinoline-based molecular tweezer that recognizes protoporphyrin IX and iron(iii) protoporphyrin IX and its application as a supramolecular photosensitizer
por: Hisamatsu, Yosuke, et al.
Publicado: (2018)

δ-Aminolaevulinic acid-induced photodynamic therapy inhibits protoporphyrin IX biosynthesis and reduces subsequent treatment efficacy in vitro
por: Gibson, S L, et al.
Publicado: (1999)

Structural Insights into the Binding and Degradation Mechanisms of Protoporphyrin IX by the Translocator Protein TSPO
por: Yeh, Pei-Shan, et al.
Publicado: (2023)

Gallium-Protoporphyrin IX Inhibits Pseudomonas aeruginosa Growth by Targeting Cytochromes
por: Hijazi, Sarah, et al.
Publicado: (2017)

Carbon dot-protoporphyrin IX conjugates for improved drug delivery and bioimaging
por: Aguilar Cosme, Jose R., et al.
Publicado: (2019)

Spectroscopic and Theoretical Investigation of β-Lactoglobulin Interactions with Hematoporphyrin and Protoporphyrin IX
por: Wang, Yun, et al.
Publicado: (2021)

Photophysical Properties of Protoporphyrin IX, Pyropheophorbide-a, and Photofrin(®) in Different Conditions
por: Myrzakhmetov, Bauyrzhan, et al.
Publicado: (2021)

SARS-CoV-2, hemoglobin and protoporphyrin IX: Interactions and perspectives
por: Courrol, Lilia Coronato, et al.
Publicado: (2021)

Association between protoporphyrin IX and sarcopenia: a cross sectional study
por: Kao, Chia-Chun, et al.
Publicado: (2021)

Effects of serum albumin on the photophysical characteristics of synthetic and endogenous protoporphyrin IX
por: Codognato, D.C.K., et al.
Publicado: (2022)

To Prevent Oxidative Stress, What about Protoporphyrin IX, Biliverdin, and Bilirubin?
por: Martínez, Ana, et al.
Publicado: (2023)

Early neoplastic and metastatic mammary tumours of transgenic mice detected by 5-aminolevulinic acid-stimulated protoporphyrin IX accumulation
por: Dorward, A M, et al.
Publicado: (2005)

Expression of Murine 5-Aminolevulinate Synthase Variants Causes Protoporphyrin IX Accumulation and Light-Induced Mammalian Cell Death
por: Fratz, Erica J., et al.
Publicado: (2014)

Mitochondrial Localization of ABC Transporter ABCG2 and Its Function in 5-Aminolevulinic Acid-Mediated Protoporphyrin IX Accumulation
por: Kobuchi, Hirotsugu, et al.
Publicado: (2012)

Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy
por: Nakayama, Taku, et al.
Publicado: (2016)

Protoporphyrin IX Stimulates Melanogenesis, Melanocyte Dendricity, and Melanosome Transport Through the cGMP/PKG Pathway
por: Lv, Jinpeng, et al.
Publicado: (2020)

MicroRNA156 (miR156) Negatively Impacts Mg-Protoporphyrin IX (Mg-Proto IX) Biosynthesis and Its Plastid-Nucleus Retrograde Signaling in Apple
por: Zheng, Qingbo, et al.
Publicado: (2020)

Protoporphyrin IX-mediated sonodynamic therapy promotes autophagy in vascular smooth muscle cells
por: Li, Qingsong, et al.
Publicado: (2017)

Biochemical basis of 5-aminolaevulinic acid-induced protoporphyrin IX accumulation: a study in patients with (pre)malignant lesions of the oesophagus.
por: Hinnen, P., et al.
Publicado: (1998)

Apoptosis and necrosis induced with light and 5-aminolaevulinic acid-derived protoporphyrin IX.
por: Noodt, B. B., et al.
Publicado: (1996)

Cannot write session to /tmp/vufind_sessions/sess_4amshf15bpvpkjk029vrshb4bi