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Down-regulation of IGHG1 enhances Protoporphyrin IX accumulation and inhibits hemin biosynthesis in colorectal cancer by suppressing the MEK-FECH axis

Immunoglobulin γ-1 heavy chain constant region (IGHG1) is a functional isoform of immunoglobulins and plays an important role in the cytolytic activity of immune effector cells. Dysregulated IGHG1 was implicated in the occurrence and development of various tumors. Protoporphyrin IX (PpIX) is an endo...

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Detalles Bibliográficos
Autores principales:	Yang, Guangjian, Li, Gang, Du, Xuemei, Zhou, Wenting, Zou, Xiaohong, Liu, Yuanfu, Lv, Hong, Li, Zhenjiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	De Gruyter 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422984/ https://www.ncbi.nlm.nih.gov/pubmed/34553073 http://dx.doi.org/10.1515/biol-2021-0098

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