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Crystal structure and Hirshfeld surface analysis of (Z)-2-amino-4-(2,6-di­chloro­phen­yl)-5-(1-hy­droxy­ethyl­idene)-6-oxo-1-phenyl-1,4,5,6-tetra­hydro­pyridine-3-carbo­nitrile

The mol­ecular conformation of the title compound, C(20)H(15)Cl(2)N(3)O(2), is stabilized by an intra­molecular O—H⋯O hydrogen bond, forming an S(6) ring motif. The central pyridine ring is almost planar [maximum deviation = 0.074 (3) Å]. It subtends dihedral angles of 86.10 (15) and 87.17 (14)°, re...

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Detalles Bibliográficos
Autores principales: Naghiyev, Farid N., Pavlova, Anastasiya V., Khrustalev, Victor N., Akkurt, Mehmet, Khalilov, Ali N., Akobirshoeva, Anzurat A., Mamedov, İbrahim G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423002/
https://www.ncbi.nlm.nih.gov/pubmed/34584764
http://dx.doi.org/10.1107/S2056989021007994
Descripción
Sumario:The mol­ecular conformation of the title compound, C(20)H(15)Cl(2)N(3)O(2), is stabilized by an intra­molecular O—H⋯O hydrogen bond, forming an S(6) ring motif. The central pyridine ring is almost planar [maximum deviation = 0.074 (3) Å]. It subtends dihedral angles of 86.10 (15) and 87.17 (14)°, respectively, with the phenyl and di­chloro­phenyl rings, which are at an angle of 21.28 (15)° to each other. The =C(—OH)CH(3) group is coplanar. In the crystal, mol­ecules are linked by inter­molecular N—H⋯N and C—H⋯N hydrogen bonds, and N—H⋯π and C—H⋯π inter­actions, forming a three-dimensional network. The most important contributions to the crystal packing are from H⋯H (33.1%), C⋯H/H⋯C (22.5%), Cl⋯H/H⋯Cl (14.1%), O⋯H/H⋯O (11.9%) and N⋯H/H⋯N (9.7%) inter­actions.