The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting

Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated interferon-stimulated genes (ISGs), which encode anti...

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Detalles Bibliográficos
Autores principales: Shaw, Andrew E., Rihn, Suzannah J., Mollentze, Nardus, Wickenhagen, Arthur, Stewart, Douglas G., Orton, Richard J., Kuchi, Srikeerthana, Bakshi, Siddharth, Collados, Mila Rodriguez, Turnbull, Matthew L., Busby, Joseph, Gu, Quan, Smollett, Katherine, Bamford, Connor G. G., Sugrue, Elena, Johnson, Paul C. D., Da Silva, Ana Filipe, Castello, Alfredo, Streicker, Daniel G., Robertson, David L., Palmarini, Massimo, Wilson, Sam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423302/
https://www.ncbi.nlm.nih.gov/pubmed/34491982
http://dx.doi.org/10.1371/journal.pbio.3001352

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