Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

Sporadic Alzheimer’s disease (AD) exclusively affects elderly people. Using direct conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age-equivalent neuronal model. AD patient-derived iNs exhibit strong neuronal transcriptome signatures characterized by downregulation o...

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Detalles Bibliográficos
Autores principales: Mertens, Jerome, Herdy, Joseph R., Traxler, Larissa, Schafer, Simon T., Schlachetzki, Johannes C.M., Böhnke, Lena, Reid, Dylan A., Lee, Hyungjun, Zangwill, Dina, Fernandes, Diana P., Agarwal, Ravi K., Lucciola, Raffaella, Zhou-Yang, Lucia, Karbacher, Lukas, Edenhofer, Frank, Stern, Shani, Horvath, Steve, Paquola, Apua C.M., Glass, Christopher K., Yuan, Shauna H., Ku, Manching, Szücs, Attila, Goldstein, Lawrence S.B., Galasko, Douglas, Gage, Fred H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423435/
https://www.ncbi.nlm.nih.gov/pubmed/33910058
http://dx.doi.org/10.1016/j.stem.2021.04.004

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