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An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens

The trafficking of specific protein cohorts to correct subcellular locations at correct times is essential for every signaling and regulatory process in biology. Gene perturbation screens could provide a powerful approach to probe the molecular mechanisms of protein trafficking, but only if protein...

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Detalles Bibliográficos
Autores principales:	Coukos, Robert, Yao, David, Sanchez, Mateo I, Strand, Eric T, Olive, Meagan E, Udeshi, Namrata D, Weissman, Jonathan S, Carr, Steven A, Bassik, Michael C, Ting, Alice Y
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423448/ https://www.ncbi.nlm.nih.gov/pubmed/34414886 http://dx.doi.org/10.7554/eLife.69142

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