Clinical Efficacy of Cefixime for the Treatment of Early Syphilis

Safe and efficacious alternative treatment options for syphilis are necessary. This randomized, 2-arm, noncomparative pilot study evaluated the efficacy of oral cefixime 400 mg in achieving a ≥4-fold rapid plasma reagin titer decrease by 3 or 6 months after treatment. The proportion of cefixime arm...

Descripción completa

Detalles Bibliográficos
Autores principales: Stafylis, Chrysovalantis, Keith, Kori, Mehta, Shivani, Tellalian, David, Burian, Pamela, Millner, Carl, Klausner, Jeffrey D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423500/
https://www.ncbi.nlm.nih.gov/pubmed/33640982
http://dx.doi.org/10.1093/cid/ciab187
Descripción
Sumario:Safe and efficacious alternative treatment options for syphilis are necessary. This randomized, 2-arm, noncomparative pilot study evaluated the efficacy of oral cefixime 400 mg in achieving a ≥4-fold rapid plasma reagin titer decrease by 3 or 6 months after treatment. The proportion of cefixime arm participants treated successfully was 87% (95% confidence interval, 69%–100%; 13/15). Clinical Trials Registration. NCT03752112.

Ejemplares similares