Clinical Efficacy of Cefixime for the Treatment of Early Syphilis

Safe and efficacious alternative treatment options for syphilis are necessary. This randomized, 2-arm, noncomparative pilot study evaluated the efficacy of oral cefixime 400 mg in achieving a ≥4-fold rapid plasma reagin titer decrease by 3 or 6 months after treatment. The proportion of cefixime arm...

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Autores principales: Stafylis, Chrysovalantis, Keith, Kori, Mehta, Shivani, Tellalian, David, Burian, Pamela, Millner, Carl, Klausner, Jeffrey D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423500/
https://www.ncbi.nlm.nih.gov/pubmed/33640982
http://dx.doi.org/10.1093/cid/ciab187
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author Stafylis, Chrysovalantis
Keith, Kori
Mehta, Shivani
Tellalian, David
Burian, Pamela
Millner, Carl
Klausner, Jeffrey D
author_facet Stafylis, Chrysovalantis
Keith, Kori
Mehta, Shivani
Tellalian, David
Burian, Pamela
Millner, Carl
Klausner, Jeffrey D
author_sort Stafylis, Chrysovalantis
collection PubMed
description Safe and efficacious alternative treatment options for syphilis are necessary. This randomized, 2-arm, noncomparative pilot study evaluated the efficacy of oral cefixime 400 mg in achieving a ≥4-fold rapid plasma reagin titer decrease by 3 or 6 months after treatment. The proportion of cefixime arm participants treated successfully was 87% (95% confidence interval, 69%–100%; 13/15). Clinical Trials Registration. NCT03752112.
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spelling pubmed-84235002021-09-09 Clinical Efficacy of Cefixime for the Treatment of Early Syphilis Stafylis, Chrysovalantis Keith, Kori Mehta, Shivani Tellalian, David Burian, Pamela Millner, Carl Klausner, Jeffrey D Clin Infect Dis Brief Reports Safe and efficacious alternative treatment options for syphilis are necessary. This randomized, 2-arm, noncomparative pilot study evaluated the efficacy of oral cefixime 400 mg in achieving a ≥4-fold rapid plasma reagin titer decrease by 3 or 6 months after treatment. The proportion of cefixime arm participants treated successfully was 87% (95% confidence interval, 69%–100%; 13/15). Clinical Trials Registration. NCT03752112. Oxford University Press 2021-02-26 /pmc/articles/PMC8423500/ /pubmed/33640982 http://dx.doi.org/10.1093/cid/ciab187 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Stafylis, Chrysovalantis
Keith, Kori
Mehta, Shivani
Tellalian, David
Burian, Pamela
Millner, Carl
Klausner, Jeffrey D
Clinical Efficacy of Cefixime for the Treatment of Early Syphilis
title Clinical Efficacy of Cefixime for the Treatment of Early Syphilis
title_full Clinical Efficacy of Cefixime for the Treatment of Early Syphilis
title_fullStr Clinical Efficacy of Cefixime for the Treatment of Early Syphilis
title_full_unstemmed Clinical Efficacy of Cefixime for the Treatment of Early Syphilis
title_short Clinical Efficacy of Cefixime for the Treatment of Early Syphilis
title_sort clinical efficacy of cefixime for the treatment of early syphilis
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423500/
https://www.ncbi.nlm.nih.gov/pubmed/33640982
http://dx.doi.org/10.1093/cid/ciab187
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