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Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar
OBJECTIVES: To explore the effective and safe medicines for treating diabetes. METHODS: Hydroalcoholic extracts of 130 medicinal plants belonging to 66 families were evaluated using porcine pancreatic lipase (PPL) inhibition and glucose uptake methods together with a literature review. RESULTS: The...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423552/ https://www.ncbi.nlm.nih.gov/pubmed/34504407 http://dx.doi.org/10.1155/2021/1424675 |
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author | Zhang, Dongdong Arunachalam, Karuppusamy Wang, Yuehu Zhang, Yu Yang, Jun Hein, Pyae Phyo Mon, Aye Mya Li, Jianwen Inta, Angkhana Yang, Xuefei |
author_facet | Zhang, Dongdong Arunachalam, Karuppusamy Wang, Yuehu Zhang, Yu Yang, Jun Hein, Pyae Phyo Mon, Aye Mya Li, Jianwen Inta, Angkhana Yang, Xuefei |
author_sort | Zhang, Dongdong |
collection | PubMed |
description | OBJECTIVES: To explore the effective and safe medicines for treating diabetes. METHODS: Hydroalcoholic extracts of 130 medicinal plants belonging to 66 families were evaluated using porcine pancreatic lipase (PPL) inhibition and glucose uptake methods together with a literature review. RESULTS: The extracts of 22 species showed the PPL inhibition activity; 18 extracts of 15 species stimulated glucose uptake in 3T3-L1 adipocytes. Among them, Mansonia gagei J.R. Drumm., Mesua ferrea L., and Centella asiatica (L.) Urb. exhibited both activities. The extracts of Caladium lindenii (André) Madison rhizomes and Azadirachta indica A. Juss. leaves presented the utmost lipase inhibitory activity with IC(50) of 6.86 ± 0.25 and 11.46 ± 0.06 μg/mL, respectively. The extracts of Coptis teeta Wall. rhizomes and Croton tiglium L. seeds stimulated the maximum glucose uptake. Ten species are reported to have antidiabetic activity for the first time. Flavonoids and triterpenoids are the dominant antidiabetic compounds in selected medicinal plants from Myanmar. CONCLUSIONS: P. zeylanica, L. cubeba, H. crenulate, M. gagei, C. teeta, and M. ferrea are worthy to advance further study according to their strong antidiabetic activities and limited research on effects in in vivo animal studies, unclear chemical constitutes, and safety. |
format | Online Article Text |
id | pubmed-8423552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-84235522021-09-08 Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar Zhang, Dongdong Arunachalam, Karuppusamy Wang, Yuehu Zhang, Yu Yang, Jun Hein, Pyae Phyo Mon, Aye Mya Li, Jianwen Inta, Angkhana Yang, Xuefei ScientificWorldJournal Research Article OBJECTIVES: To explore the effective and safe medicines for treating diabetes. METHODS: Hydroalcoholic extracts of 130 medicinal plants belonging to 66 families were evaluated using porcine pancreatic lipase (PPL) inhibition and glucose uptake methods together with a literature review. RESULTS: The extracts of 22 species showed the PPL inhibition activity; 18 extracts of 15 species stimulated glucose uptake in 3T3-L1 adipocytes. Among them, Mansonia gagei J.R. Drumm., Mesua ferrea L., and Centella asiatica (L.) Urb. exhibited both activities. The extracts of Caladium lindenii (André) Madison rhizomes and Azadirachta indica A. Juss. leaves presented the utmost lipase inhibitory activity with IC(50) of 6.86 ± 0.25 and 11.46 ± 0.06 μg/mL, respectively. The extracts of Coptis teeta Wall. rhizomes and Croton tiglium L. seeds stimulated the maximum glucose uptake. Ten species are reported to have antidiabetic activity for the first time. Flavonoids and triterpenoids are the dominant antidiabetic compounds in selected medicinal plants from Myanmar. CONCLUSIONS: P. zeylanica, L. cubeba, H. crenulate, M. gagei, C. teeta, and M. ferrea are worthy to advance further study according to their strong antidiabetic activities and limited research on effects in in vivo animal studies, unclear chemical constitutes, and safety. Hindawi 2021-08-26 /pmc/articles/PMC8423552/ /pubmed/34504407 http://dx.doi.org/10.1155/2021/1424675 Text en Copyright © 2021 Dongdong Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhang, Dongdong Arunachalam, Karuppusamy Wang, Yuehu Zhang, Yu Yang, Jun Hein, Pyae Phyo Mon, Aye Mya Li, Jianwen Inta, Angkhana Yang, Xuefei Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar |
title | Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar |
title_full | Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar |
title_fullStr | Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar |
title_full_unstemmed | Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar |
title_short | Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar |
title_sort | evaluation on antidiabetic properties of medicinal plants from myanmar |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423552/ https://www.ncbi.nlm.nih.gov/pubmed/34504407 http://dx.doi.org/10.1155/2021/1424675 |
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