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Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar

OBJECTIVES: To explore the effective and safe medicines for treating diabetes. METHODS: Hydroalcoholic extracts of 130 medicinal plants belonging to 66 families were evaluated using porcine pancreatic lipase (PPL) inhibition and glucose uptake methods together with a literature review. RESULTS: The...

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Autores principales: Zhang, Dongdong, Arunachalam, Karuppusamy, Wang, Yuehu, Zhang, Yu, Yang, Jun, Hein, Pyae Phyo, Mon, Aye Mya, Li, Jianwen, Inta, Angkhana, Yang, Xuefei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423552/
https://www.ncbi.nlm.nih.gov/pubmed/34504407
http://dx.doi.org/10.1155/2021/1424675
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author Zhang, Dongdong
Arunachalam, Karuppusamy
Wang, Yuehu
Zhang, Yu
Yang, Jun
Hein, Pyae Phyo
Mon, Aye Mya
Li, Jianwen
Inta, Angkhana
Yang, Xuefei
author_facet Zhang, Dongdong
Arunachalam, Karuppusamy
Wang, Yuehu
Zhang, Yu
Yang, Jun
Hein, Pyae Phyo
Mon, Aye Mya
Li, Jianwen
Inta, Angkhana
Yang, Xuefei
author_sort Zhang, Dongdong
collection PubMed
description OBJECTIVES: To explore the effective and safe medicines for treating diabetes. METHODS: Hydroalcoholic extracts of 130 medicinal plants belonging to 66 families were evaluated using porcine pancreatic lipase (PPL) inhibition and glucose uptake methods together with a literature review. RESULTS: The extracts of 22 species showed the PPL inhibition activity; 18 extracts of 15 species stimulated glucose uptake in 3T3-L1 adipocytes. Among them, Mansonia gagei J.R. Drumm., Mesua ferrea L., and Centella asiatica (L.) Urb. exhibited both activities. The extracts of Caladium lindenii (André) Madison rhizomes and Azadirachta indica A. Juss. leaves presented the utmost lipase inhibitory activity with IC(50) of 6.86 ± 0.25 and 11.46 ± 0.06 μg/mL, respectively. The extracts of Coptis teeta Wall. rhizomes and Croton tiglium L. seeds stimulated the maximum glucose uptake. Ten species are reported to have antidiabetic activity for the first time. Flavonoids and triterpenoids are the dominant antidiabetic compounds in selected medicinal plants from Myanmar. CONCLUSIONS: P. zeylanica, L. cubeba, H. crenulate, M. gagei, C. teeta, and M. ferrea are worthy to advance further study according to their strong antidiabetic activities and limited research on effects in in vivo animal studies, unclear chemical constitutes, and safety.
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spelling pubmed-84235522021-09-08 Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar Zhang, Dongdong Arunachalam, Karuppusamy Wang, Yuehu Zhang, Yu Yang, Jun Hein, Pyae Phyo Mon, Aye Mya Li, Jianwen Inta, Angkhana Yang, Xuefei ScientificWorldJournal Research Article OBJECTIVES: To explore the effective and safe medicines for treating diabetes. METHODS: Hydroalcoholic extracts of 130 medicinal plants belonging to 66 families were evaluated using porcine pancreatic lipase (PPL) inhibition and glucose uptake methods together with a literature review. RESULTS: The extracts of 22 species showed the PPL inhibition activity; 18 extracts of 15 species stimulated glucose uptake in 3T3-L1 adipocytes. Among them, Mansonia gagei J.R. Drumm., Mesua ferrea L., and Centella asiatica (L.) Urb. exhibited both activities. The extracts of Caladium lindenii (André) Madison rhizomes and Azadirachta indica A. Juss. leaves presented the utmost lipase inhibitory activity with IC(50) of 6.86 ± 0.25 and 11.46 ± 0.06 μg/mL, respectively. The extracts of Coptis teeta Wall. rhizomes and Croton tiglium L. seeds stimulated the maximum glucose uptake. Ten species are reported to have antidiabetic activity for the first time. Flavonoids and triterpenoids are the dominant antidiabetic compounds in selected medicinal plants from Myanmar. CONCLUSIONS: P. zeylanica, L. cubeba, H. crenulate, M. gagei, C. teeta, and M. ferrea are worthy to advance further study according to their strong antidiabetic activities and limited research on effects in in vivo animal studies, unclear chemical constitutes, and safety. Hindawi 2021-08-26 /pmc/articles/PMC8423552/ /pubmed/34504407 http://dx.doi.org/10.1155/2021/1424675 Text en Copyright © 2021 Dongdong Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Dongdong
Arunachalam, Karuppusamy
Wang, Yuehu
Zhang, Yu
Yang, Jun
Hein, Pyae Phyo
Mon, Aye Mya
Li, Jianwen
Inta, Angkhana
Yang, Xuefei
Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar
title Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar
title_full Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar
title_fullStr Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar
title_full_unstemmed Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar
title_short Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar
title_sort evaluation on antidiabetic properties of medicinal plants from myanmar
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423552/
https://www.ncbi.nlm.nih.gov/pubmed/34504407
http://dx.doi.org/10.1155/2021/1424675
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