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Uninterrupted Direct Oral Anticoagulants Without a Change in Regimen for Catheter Ablation for Atrial Fibrillation Is an Acceptable Protocol
Background: In patients undergoing catheter ablation (CA) for atrial fibrillation (AF), the use of uninterrupted direct oral anticoagulants (DOACs) is the current protocol. This study evaluated bleeding complications following the uninterrupted use of 4 DOACs in patients undergoing CA for AF without...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japanese Circulation Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423616/ https://www.ncbi.nlm.nih.gov/pubmed/34568626 http://dx.doi.org/10.1253/circrep.CR-20-0139 |
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author | Oshima, Tsukasa Fujiu, Katsuhito Matsunaga, Hiroshi Matsuda, Jun Matsubara, Takumi Saga, Akiko Yoshida, Yuriko Shimizu, Yu Hasumi, Eriko Oguri, Gaku Kojima, Toshiya Komuro, Issei |
author_facet | Oshima, Tsukasa Fujiu, Katsuhito Matsunaga, Hiroshi Matsuda, Jun Matsubara, Takumi Saga, Akiko Yoshida, Yuriko Shimizu, Yu Hasumi, Eriko Oguri, Gaku Kojima, Toshiya Komuro, Issei |
author_sort | Oshima, Tsukasa |
collection | PubMed |
description | Background: In patients undergoing catheter ablation (CA) for atrial fibrillation (AF), the use of uninterrupted direct oral anticoagulants (DOACs) is the current protocol. This study evaluated bleeding complications following the uninterrupted use of 4 DOACs in patients undergoing CA for AF without any change in the dosing regimen. Moreover, we assessed differences between once- and twice-daily DOAC dosing in patients undergoing CA for AF who continued on DOACs without any change in the dosing regimen. Methods and Results: This study was a retrospective single-center cohort study of consecutive patients. All patients continued DOACs without interruption or changes to the dosing schedule, even in the case of morning procedures. The primary endpoint was the incidence of major bleeding events within the first 30 days after CA. In all, 710 consecutive patients were included in the study. Bleeding complications were less frequent in the uninterrupted twice- than once-daily DOACs group. However, the incidence of cardiac tamponade across all DOACs was low (0.98%; 7/710), suggesting that uninterrupted DOACs without changes to the dosing regimen may be an acceptable strategy. The rate of total bleeding events, including minor bleeding (12/710; 1.6%), was also satisfactory. Conclusions: Uninterrupted DOACs without any change in dosing regimen for patients undergoing CA for AF is acceptable. Bleeding complications may be less frequent in patients receiving DOACs twice rather than once daily. |
format | Online Article Text |
id | pubmed-8423616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Japanese Circulation Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-84236162021-09-24 Uninterrupted Direct Oral Anticoagulants Without a Change in Regimen for Catheter Ablation for Atrial Fibrillation Is an Acceptable Protocol Oshima, Tsukasa Fujiu, Katsuhito Matsunaga, Hiroshi Matsuda, Jun Matsubara, Takumi Saga, Akiko Yoshida, Yuriko Shimizu, Yu Hasumi, Eriko Oguri, Gaku Kojima, Toshiya Komuro, Issei Circ Rep Original article Background: In patients undergoing catheter ablation (CA) for atrial fibrillation (AF), the use of uninterrupted direct oral anticoagulants (DOACs) is the current protocol. This study evaluated bleeding complications following the uninterrupted use of 4 DOACs in patients undergoing CA for AF without any change in the dosing regimen. Moreover, we assessed differences between once- and twice-daily DOAC dosing in patients undergoing CA for AF who continued on DOACs without any change in the dosing regimen. Methods and Results: This study was a retrospective single-center cohort study of consecutive patients. All patients continued DOACs without interruption or changes to the dosing schedule, even in the case of morning procedures. The primary endpoint was the incidence of major bleeding events within the first 30 days after CA. In all, 710 consecutive patients were included in the study. Bleeding complications were less frequent in the uninterrupted twice- than once-daily DOACs group. However, the incidence of cardiac tamponade across all DOACs was low (0.98%; 7/710), suggesting that uninterrupted DOACs without changes to the dosing regimen may be an acceptable strategy. The rate of total bleeding events, including minor bleeding (12/710; 1.6%), was also satisfactory. Conclusions: Uninterrupted DOACs without any change in dosing regimen for patients undergoing CA for AF is acceptable. Bleeding complications may be less frequent in patients receiving DOACs twice rather than once daily. The Japanese Circulation Society 2021-07-30 /pmc/articles/PMC8423616/ /pubmed/34568626 http://dx.doi.org/10.1253/circrep.CR-20-0139 Text en Copyright © 2021, THE JAPANESE CIRCULATION SOCIETY https://creativecommons.org/licenses/by-nc-nd/4.0/This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license. |
spellingShingle | Original article Oshima, Tsukasa Fujiu, Katsuhito Matsunaga, Hiroshi Matsuda, Jun Matsubara, Takumi Saga, Akiko Yoshida, Yuriko Shimizu, Yu Hasumi, Eriko Oguri, Gaku Kojima, Toshiya Komuro, Issei Uninterrupted Direct Oral Anticoagulants Without a Change in Regimen for Catheter Ablation for Atrial Fibrillation Is an Acceptable Protocol |
title | Uninterrupted Direct Oral Anticoagulants Without a Change in Regimen for Catheter Ablation for Atrial Fibrillation Is an Acceptable Protocol |
title_full | Uninterrupted Direct Oral Anticoagulants Without a Change in Regimen for Catheter Ablation for Atrial Fibrillation Is an Acceptable Protocol |
title_fullStr | Uninterrupted Direct Oral Anticoagulants Without a Change in Regimen for Catheter Ablation for Atrial Fibrillation Is an Acceptable Protocol |
title_full_unstemmed | Uninterrupted Direct Oral Anticoagulants Without a Change in Regimen for Catheter Ablation for Atrial Fibrillation Is an Acceptable Protocol |
title_short | Uninterrupted Direct Oral Anticoagulants Without a Change in Regimen for Catheter Ablation for Atrial Fibrillation Is an Acceptable Protocol |
title_sort | uninterrupted direct oral anticoagulants without a change in regimen for catheter ablation for atrial fibrillation is an acceptable protocol |
topic | Original article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423616/ https://www.ncbi.nlm.nih.gov/pubmed/34568626 http://dx.doi.org/10.1253/circrep.CR-20-0139 |
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