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Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy

Pretreatment of B-cell lymphoma patients with immunostimulatory gene therapy using armed oncolytic viruses may prime tumor lesions for subsequent chimeric antigen receptor (CAR) T-cell therapy, thereby enhancing CAR T-cell functionality and possibly increasing response rates in patients. LOAd703 (de...

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Detalles Bibliográficos
Autores principales:	Wenthe, Jessica, Naseri, Sedigheh, Labani-Motlagh, Alireza, Enblad, Gunilla, Wikström, Kristina I., Eriksson, Emma, Loskog, Angelica, Lövgren, Tanja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423656/ https://www.ncbi.nlm.nih.gov/pubmed/33666760 http://dx.doi.org/10.1007/s00262-021-02895-7

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