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The association of the 5-HTTLPR polymorphism and the response to different stressors in healthy males
The experience of stress is related to individual wellbeing and vulnerability to psychopathology. Therefore, understanding the determinants of individual differences in stress reactivity is of great concern from a clinical perspective. The functional promotor polymorphism of the serotonin transporte...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423678/ https://www.ncbi.nlm.nih.gov/pubmed/34374855 http://dx.doi.org/10.1007/s00702-021-02390-4 |
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author | Kuhn, Leandra Noack, Hannes Skoluda, Nadine Wagels, Lisa Röhr, Ann-Kristin Schulte, Christina Eisenkolb, Sana Nieratschker, Vanessa Derntl, Birgit Habel, Ute |
author_facet | Kuhn, Leandra Noack, Hannes Skoluda, Nadine Wagels, Lisa Röhr, Ann-Kristin Schulte, Christina Eisenkolb, Sana Nieratschker, Vanessa Derntl, Birgit Habel, Ute |
author_sort | Kuhn, Leandra |
collection | PubMed |
description | The experience of stress is related to individual wellbeing and vulnerability to psychopathology. Therefore, understanding the determinants of individual differences in stress reactivity is of great concern from a clinical perspective. The functional promotor polymorphism of the serotonin transporter gene (5-HTTLPR/rs25531) is such a factor, which has been linked to the acute stress response as well as the adverse effect of life stressors. In the present study, we compared the impact of two different stress induction protocols (Maastricht Acute Stress Test and ScanSTRESS) and the respective control conditions on affective ratings, salivary cortisol levels and cognitive performance. To this end, 156 healthy young males were tested and genotyped for the 5-HTTLPR/rs25531 polymorphism. While combined physiological and psychological stress in the MAST led to a greater cortisol increase compared to control conditions as well as the psychosocial ScanSTRESS, subjective stress ratings were highest in the ScanSTRESS condition. Stress induction in general affected working memory capacity but not response inhibition. Subjective stress was also influenced by 5-HTTLPR/rs25531 genotype with the high expression group showing lower stress ratings than lower expression groups. In line with previous research, we identified the low expression variant of the serotonin transporter gene as a risk factor for increased stress reactivity. While some dimensions of the human stress response may be stressor specific, cognitive outcomes such as working memory performance are influenced by stress in general. Different pathways of stress processing and possible underlying mechanisms are discussed. |
format | Online Article Text |
id | pubmed-8423678 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-84236782021-09-09 The association of the 5-HTTLPR polymorphism and the response to different stressors in healthy males Kuhn, Leandra Noack, Hannes Skoluda, Nadine Wagels, Lisa Röhr, Ann-Kristin Schulte, Christina Eisenkolb, Sana Nieratschker, Vanessa Derntl, Birgit Habel, Ute J Neural Transm (Vienna) Psychiatry and Preclinical Psychiatric Studies - Original Article The experience of stress is related to individual wellbeing and vulnerability to psychopathology. Therefore, understanding the determinants of individual differences in stress reactivity is of great concern from a clinical perspective. The functional promotor polymorphism of the serotonin transporter gene (5-HTTLPR/rs25531) is such a factor, which has been linked to the acute stress response as well as the adverse effect of life stressors. In the present study, we compared the impact of two different stress induction protocols (Maastricht Acute Stress Test and ScanSTRESS) and the respective control conditions on affective ratings, salivary cortisol levels and cognitive performance. To this end, 156 healthy young males were tested and genotyped for the 5-HTTLPR/rs25531 polymorphism. While combined physiological and psychological stress in the MAST led to a greater cortisol increase compared to control conditions as well as the psychosocial ScanSTRESS, subjective stress ratings were highest in the ScanSTRESS condition. Stress induction in general affected working memory capacity but not response inhibition. Subjective stress was also influenced by 5-HTTLPR/rs25531 genotype with the high expression group showing lower stress ratings than lower expression groups. In line with previous research, we identified the low expression variant of the serotonin transporter gene as a risk factor for increased stress reactivity. While some dimensions of the human stress response may be stressor specific, cognitive outcomes such as working memory performance are influenced by stress in general. Different pathways of stress processing and possible underlying mechanisms are discussed. Springer Vienna 2021-08-10 2021 /pmc/articles/PMC8423678/ /pubmed/34374855 http://dx.doi.org/10.1007/s00702-021-02390-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Psychiatry and Preclinical Psychiatric Studies - Original Article Kuhn, Leandra Noack, Hannes Skoluda, Nadine Wagels, Lisa Röhr, Ann-Kristin Schulte, Christina Eisenkolb, Sana Nieratschker, Vanessa Derntl, Birgit Habel, Ute The association of the 5-HTTLPR polymorphism and the response to different stressors in healthy males |
title | The association of the 5-HTTLPR polymorphism and the response to different stressors in healthy males |
title_full | The association of the 5-HTTLPR polymorphism and the response to different stressors in healthy males |
title_fullStr | The association of the 5-HTTLPR polymorphism and the response to different stressors in healthy males |
title_full_unstemmed | The association of the 5-HTTLPR polymorphism and the response to different stressors in healthy males |
title_short | The association of the 5-HTTLPR polymorphism and the response to different stressors in healthy males |
title_sort | association of the 5-httlpr polymorphism and the response to different stressors in healthy males |
topic | Psychiatry and Preclinical Psychiatric Studies - Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423678/ https://www.ncbi.nlm.nih.gov/pubmed/34374855 http://dx.doi.org/10.1007/s00702-021-02390-4 |
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