Adoptive immunotherapy with transient anti-CD4 treatment enhances anti-tumor response by increasing IL-18Rα(hi) CD8(+) T cells

Adoptive T cell therapy (ACT) requires lymphodepletion preconditioning to eliminate immune-suppressive elements and enable efficient engraftment of adoptively transferred tumor-reactive T cells. As anti-CD4 monoclonal antibody depletes CD4(+) immune-suppressive cells, the combination of anti-CD4 tre...

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Detalles Bibliográficos
Autores principales: Kim, Seon-Hee, Cho, Eunjung, Kim, Yu I., Han, Chungyong, Choi, Beom K., Kwon, Byoung S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423719/
https://www.ncbi.nlm.nih.gov/pubmed/34493727
http://dx.doi.org/10.1038/s41467-021-25559-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423719/
https://www.ncbi.nlm.nih.gov/pubmed/34493727
http://dx.doi.org/10.1038/s41467-021-25559-7

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