Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer

CARM1 is often overexpressed in human cancers including in ovarian cancer. However, therapeutic approaches based on CARM1 expression remain to be an unmet need. Cancer cells exploit adaptive responses such as the endoplasmic reticulum (ER) stress response for their survival through activating pathwa...

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Detalles Bibliográficos
Autores principales: Lin, Jianhuang, Liu, Heng, Fukumoto, Takeshi, Zundell, Joseph, Yan, Qingqing, Tang, Chih-Hang Anthony, Wu, Shuai, Zhou, Wei, Guo, Dajiang, Karakashev, Sergey, Hu, Chih-Chi Andrew, Sarma, Kavitha, Kossenkov, Andrew V., Zhang, Rugang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423755/
https://www.ncbi.nlm.nih.gov/pubmed/34493732
http://dx.doi.org/10.1038/s41467-021-25684-3

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