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Evaluating characteristics associated with the mortality among invasive ventilation COIVD -19 patients()

BACKGROUND: Coronavirus disease 2019 (COVID-19) is associated acute respiratory distress syndrome that leads to intensive care unit admission and subsequent need of invasive ventilation. The aim of this study is to evaluate mortality rate and associated parameters among COVID 19 patients under invas...

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Autores principales: Farzan, Nina, Vahabi, Sepideh, Hashemi Madani, Shima Sadat, Farzan, Behrooz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423777/
https://www.ncbi.nlm.nih.gov/pubmed/34512967
http://dx.doi.org/10.1016/j.amsu.2021.102832
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author Farzan, Nina
Vahabi, Sepideh
Hashemi Madani, Shima Sadat
Farzan, Behrooz
author_facet Farzan, Nina
Vahabi, Sepideh
Hashemi Madani, Shima Sadat
Farzan, Behrooz
author_sort Farzan, Nina
collection PubMed
description BACKGROUND: Coronavirus disease 2019 (COVID-19) is associated acute respiratory distress syndrome that leads to intensive care unit admission and subsequent need of invasive ventilation. The aim of this study is to evaluate mortality rate and associated parameters among COVID 19 patients under invasive ventilation. METHODS: In this retrospective studies, COVID 19 patients referred to our center we evaluated. The data regarding demographic characteristics, comorbidities, biochemical and radiographic findings, need of invasive ventilation and mortality were collected and recorded for all the patients. Statistical analysis was performed to evaluate the risk of mortality in invasive ventilation patients relative to each risk factor or paraclinical or clinical feature. RESULTS: Among patients included in the study, 63 patients underwent invasive ventilation where 53 (84%) of these died. The mortality rate among invasive ventilation was significantly associated with advanced age, p = 0.006 whereas it was not significantly associated with smoking, gender, c-reactive protein, platelet count, hypertension, lymphopenia, leukopenia, creatinine kinase, addiction, blood urea nitrogen to creatinine ratio, malignancy, cough, fever, nausea, chronic obstructive pulmonary disease and erythrocyte sedimentation rate. CONCLUSIONS: The findings of our study indicate that advanced age can increase the risk of mortality in COVID 19 patients under invasive ventilation whereas, mortality among invasive ventilation patients is high, irrespective of their characteristic. Guidelines are therefore, required regarding the use of invasive ventilation among these patients.
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spelling pubmed-84237772021-09-08 Evaluating characteristics associated with the mortality among invasive ventilation COIVD -19 patients() Farzan, Nina Vahabi, Sepideh Hashemi Madani, Shima Sadat Farzan, Behrooz Ann Med Surg (Lond) Cohort Study BACKGROUND: Coronavirus disease 2019 (COVID-19) is associated acute respiratory distress syndrome that leads to intensive care unit admission and subsequent need of invasive ventilation. The aim of this study is to evaluate mortality rate and associated parameters among COVID 19 patients under invasive ventilation. METHODS: In this retrospective studies, COVID 19 patients referred to our center we evaluated. The data regarding demographic characteristics, comorbidities, biochemical and radiographic findings, need of invasive ventilation and mortality were collected and recorded for all the patients. Statistical analysis was performed to evaluate the risk of mortality in invasive ventilation patients relative to each risk factor or paraclinical or clinical feature. RESULTS: Among patients included in the study, 63 patients underwent invasive ventilation where 53 (84%) of these died. The mortality rate among invasive ventilation was significantly associated with advanced age, p = 0.006 whereas it was not significantly associated with smoking, gender, c-reactive protein, platelet count, hypertension, lymphopenia, leukopenia, creatinine kinase, addiction, blood urea nitrogen to creatinine ratio, malignancy, cough, fever, nausea, chronic obstructive pulmonary disease and erythrocyte sedimentation rate. CONCLUSIONS: The findings of our study indicate that advanced age can increase the risk of mortality in COVID 19 patients under invasive ventilation whereas, mortality among invasive ventilation patients is high, irrespective of their characteristic. Guidelines are therefore, required regarding the use of invasive ventilation among these patients. Elsevier 2021-09-08 /pmc/articles/PMC8423777/ /pubmed/34512967 http://dx.doi.org/10.1016/j.amsu.2021.102832 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Cohort Study
Farzan, Nina
Vahabi, Sepideh
Hashemi Madani, Shima Sadat
Farzan, Behrooz
Evaluating characteristics associated with the mortality among invasive ventilation COIVD -19 patients()
title Evaluating characteristics associated with the mortality among invasive ventilation COIVD -19 patients()
title_full Evaluating characteristics associated with the mortality among invasive ventilation COIVD -19 patients()
title_fullStr Evaluating characteristics associated with the mortality among invasive ventilation COIVD -19 patients()
title_full_unstemmed Evaluating characteristics associated with the mortality among invasive ventilation COIVD -19 patients()
title_short Evaluating characteristics associated with the mortality among invasive ventilation COIVD -19 patients()
title_sort evaluating characteristics associated with the mortality among invasive ventilation coivd -19 patients()
topic Cohort Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423777/
https://www.ncbi.nlm.nih.gov/pubmed/34512967
http://dx.doi.org/10.1016/j.amsu.2021.102832
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