In silico exploration of enzymes involved in sialic acid biosynthesis and their possible role in SARS-CoV-2 infection

Salivary glands are considered important targets of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recent evidence suggests that along with angiotensin converting enzyme 2, certain cell surface sialic acids (Sia) may function as receptors for binding SARS-CoV-2 spike protein...

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Detalles Bibliográficos
Autores principales: Divya, V.C., Saravanakarthikeyan, Balasubramanian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Oral Biology. Published by Elsevier B.V. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423778/
https://www.ncbi.nlm.nih.gov/pubmed/34506921
http://dx.doi.org/10.1016/j.job.2021.08.004
Descripción
Sumario:Salivary glands are considered important targets of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recent evidence suggests that along with angiotensin converting enzyme 2, certain cell surface sialic acids (Sia) may function as receptors for binding SARS-CoV-2 spike protein. Over 50 forms of Sia have been identified in nature, with N-acetylneuraminic acid (Neu5Ac) being the most abundant. We explored the Human Protein Atlas repository to analyze important enzymes in Neu5Ac biosynthesis and propose a hypothesis that further highlights the significance of salivary glands in coronavirus disease 19 (COVID-19). This work may facilitate research into targeted drug therapies for COVID-19.

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