In silico exploration of enzymes involved in sialic acid biosynthesis and their possible role in SARS-CoV-2 infection

Salivary glands are considered important targets of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recent evidence suggests that along with angiotensin converting enzyme 2, certain cell surface sialic acids (Sia) may function as receptors for binding SARS-CoV-2 spike protein...

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Autores principales: Divya, V.C., Saravanakarthikeyan, Balasubramanian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Oral Biology. Published by Elsevier B.V. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423778/
https://www.ncbi.nlm.nih.gov/pubmed/34506921
http://dx.doi.org/10.1016/j.job.2021.08.004
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author Divya, V.C.
Saravanakarthikeyan, Balasubramanian
author_facet Divya, V.C.
Saravanakarthikeyan, Balasubramanian
author_sort Divya, V.C.
collection PubMed
description Salivary glands are considered important targets of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recent evidence suggests that along with angiotensin converting enzyme 2, certain cell surface sialic acids (Sia) may function as receptors for binding SARS-CoV-2 spike protein. Over 50 forms of Sia have been identified in nature, with N-acetylneuraminic acid (Neu5Ac) being the most abundant. We explored the Human Protein Atlas repository to analyze important enzymes in Neu5Ac biosynthesis and propose a hypothesis that further highlights the significance of salivary glands in coronavirus disease 19 (COVID-19). This work may facilitate research into targeted drug therapies for COVID-19.
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spelling pubmed-84237782021-09-08 In silico exploration of enzymes involved in sialic acid biosynthesis and their possible role in SARS-CoV-2 infection Divya, V.C. Saravanakarthikeyan, Balasubramanian J Oral Biosci Short Communication Salivary glands are considered important targets of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recent evidence suggests that along with angiotensin converting enzyme 2, certain cell surface sialic acids (Sia) may function as receptors for binding SARS-CoV-2 spike protein. Over 50 forms of Sia have been identified in nature, with N-acetylneuraminic acid (Neu5Ac) being the most abundant. We explored the Human Protein Atlas repository to analyze important enzymes in Neu5Ac biosynthesis and propose a hypothesis that further highlights the significance of salivary glands in coronavirus disease 19 (COVID-19). This work may facilitate research into targeted drug therapies for COVID-19. Japanese Association for Oral Biology. Published by Elsevier B.V. 2021-12 2021-09-08 /pmc/articles/PMC8423778/ /pubmed/34506921 http://dx.doi.org/10.1016/j.job.2021.08.004 Text en © 2021 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Divya, V.C.
Saravanakarthikeyan, Balasubramanian
In silico exploration of enzymes involved in sialic acid biosynthesis and their possible role in SARS-CoV-2 infection
title In silico exploration of enzymes involved in sialic acid biosynthesis and their possible role in SARS-CoV-2 infection
title_full In silico exploration of enzymes involved in sialic acid biosynthesis and their possible role in SARS-CoV-2 infection
title_fullStr In silico exploration of enzymes involved in sialic acid biosynthesis and their possible role in SARS-CoV-2 infection
title_full_unstemmed In silico exploration of enzymes involved in sialic acid biosynthesis and their possible role in SARS-CoV-2 infection
title_short In silico exploration of enzymes involved in sialic acid biosynthesis and their possible role in SARS-CoV-2 infection
title_sort in silico exploration of enzymes involved in sialic acid biosynthesis and their possible role in sars-cov-2 infection
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423778/
https://www.ncbi.nlm.nih.gov/pubmed/34506921
http://dx.doi.org/10.1016/j.job.2021.08.004
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