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A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease

The SARS-CoV-2 papain-like protease (PLpro) is a target for antiviral drug development. It is essential for processing viral polyproteins for replication and functions in host immune evasion by cleaving ubiquitin (Ub) and ubiquitin-like protein (Ubl) conjugates. While highly conserved, SARS-CoV-2 an...

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Detalles Bibliográficos
Autores principales:	Patchett, Stephanie, Lv, Zongyang, Rut, Wioletta, Békés, Miklos, Drag, Marcin, Olsen, Shaun K., Huang, Tony T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Author(s). 2021
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423903/ https://www.ncbi.nlm.nih.gov/pubmed/34547223 http://dx.doi.org/10.1016/j.celrep.2021.109754

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