Imaging Familial and Sporadic Neurodegenerative Disorders Associated with Parkinsonism

In this paper, the structural and functional imaging changes associated with sporadic and genetic Parkinson’s disease and atypical Parkinsonian variants are reviewed. The role of imaging for supporting diagnosis and detecting subclinical disease is discussed, and the potential use and drawbacks of u...

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Autor principal: Brooks, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423977/
https://www.ncbi.nlm.nih.gov/pubmed/33432494
http://dx.doi.org/10.1007/s13311-020-00994-4
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author Brooks, David J.
author_facet Brooks, David J.
author_sort Brooks, David J.
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description In this paper, the structural and functional imaging changes associated with sporadic and genetic Parkinson’s disease and atypical Parkinsonian variants are reviewed. The role of imaging for supporting diagnosis and detecting subclinical disease is discussed, and the potential use and drawbacks of using imaging biomarkers for monitoring disease progression is debated. Imaging changes associated with nonmotor complications of PD are presented. The similarities and differences in imaging findings in Lewy body dementia, Parkinson’s disease dementia, and Alzheimer’s disease are discussed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13311-020-00994-4.
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spelling pubmed-84239772021-09-29 Imaging Familial and Sporadic Neurodegenerative Disorders Associated with Parkinsonism Brooks, David J. Neurotherapeutics Review In this paper, the structural and functional imaging changes associated with sporadic and genetic Parkinson’s disease and atypical Parkinsonian variants are reviewed. The role of imaging for supporting diagnosis and detecting subclinical disease is discussed, and the potential use and drawbacks of using imaging biomarkers for monitoring disease progression is debated. Imaging changes associated with nonmotor complications of PD are presented. The similarities and differences in imaging findings in Lewy body dementia, Parkinson’s disease dementia, and Alzheimer’s disease are discussed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13311-020-00994-4. Springer International Publishing 2021-01-11 2021-04 /pmc/articles/PMC8423977/ /pubmed/33432494 http://dx.doi.org/10.1007/s13311-020-00994-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Brooks, David J.
Imaging Familial and Sporadic Neurodegenerative Disorders Associated with Parkinsonism
title Imaging Familial and Sporadic Neurodegenerative Disorders Associated with Parkinsonism
title_full Imaging Familial and Sporadic Neurodegenerative Disorders Associated with Parkinsonism
title_fullStr Imaging Familial and Sporadic Neurodegenerative Disorders Associated with Parkinsonism
title_full_unstemmed Imaging Familial and Sporadic Neurodegenerative Disorders Associated with Parkinsonism
title_short Imaging Familial and Sporadic Neurodegenerative Disorders Associated with Parkinsonism
title_sort imaging familial and sporadic neurodegenerative disorders associated with parkinsonism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423977/
https://www.ncbi.nlm.nih.gov/pubmed/33432494
http://dx.doi.org/10.1007/s13311-020-00994-4
work_keys_str_mv AT brooksdavidj imagingfamilialandsporadicneurodegenerativedisordersassociatedwithparkinsonism

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