Cargando…

Mesenchymal Stem Cells Suppress Severe Asthma by Directly Regulating Th2 Cells and Type 2 Innate Lymphoid Cells

Patients with severe asthma have unmet clinical needs for effective and safe therapies. One possibility may be mesenchymal stem cell (MSC) therapy, which can improve asthma in murine models. However, it remains unclear how MSCs exert their beneficial effects in asthma. Here, we examined the effect o...

Descripción completa

Detalles Bibliográficos
Autores principales: Shin, Jae Woo, Ryu, Seungwon, Ham, Jongho, Jung, Keehoon, Lee, Sangho, Chung, Doo Hyun, Kang, Hye-Ryun, Kim, Hye Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424137/
https://www.ncbi.nlm.nih.gov/pubmed/34462397
http://dx.doi.org/10.14348/molcells.2021.0101
_version_ 1783749610820337664
author Shin, Jae Woo
Ryu, Seungwon
Ham, Jongho
Jung, Keehoon
Lee, Sangho
Chung, Doo Hyun
Kang, Hye-Ryun
Kim, Hye Young
author_facet Shin, Jae Woo
Ryu, Seungwon
Ham, Jongho
Jung, Keehoon
Lee, Sangho
Chung, Doo Hyun
Kang, Hye-Ryun
Kim, Hye Young
author_sort Shin, Jae Woo
collection PubMed
description Patients with severe asthma have unmet clinical needs for effective and safe therapies. One possibility may be mesenchymal stem cell (MSC) therapy, which can improve asthma in murine models. However, it remains unclear how MSCs exert their beneficial effects in asthma. Here, we examined the effect of human umbilical cord blood-derived MSCs (hUC-MSC) on two mouse models of severe asthma, namely, Alternaria alternata-induced and house dust mite (HDM)/diesel exhaust particle (DEP)-induced asthma. hUC-MSC treatment attenuated lung type 2 (Th2 and type 2 innate lymphoid cell) inflammation in both models. However, these effects were only observed with particular treatment routes and timings. In vitro co-culture showed that hUC-MSC directly downregulated the interleukin (IL)-5 and IL-13 production of differentiated mouse Th2 cells and peripheral blood mononuclear cells from asthma patients. Thus, these results showed that hUC-MSC treatment can ameliorate asthma by suppressing the asthmogenic cytokine production of effector cells. However, the successful clinical application of MSCs in the future is likely to require careful optimization of the route, dosage, and timing.
format Online
Article
Text
id pubmed-8424137
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Korean Society for Molecular and Cellular Biology
record_format MEDLINE/PubMed
spelling pubmed-84241372021-09-20 Mesenchymal Stem Cells Suppress Severe Asthma by Directly Regulating Th2 Cells and Type 2 Innate Lymphoid Cells Shin, Jae Woo Ryu, Seungwon Ham, Jongho Jung, Keehoon Lee, Sangho Chung, Doo Hyun Kang, Hye-Ryun Kim, Hye Young Mol Cells Research Article Patients with severe asthma have unmet clinical needs for effective and safe therapies. One possibility may be mesenchymal stem cell (MSC) therapy, which can improve asthma in murine models. However, it remains unclear how MSCs exert their beneficial effects in asthma. Here, we examined the effect of human umbilical cord blood-derived MSCs (hUC-MSC) on two mouse models of severe asthma, namely, Alternaria alternata-induced and house dust mite (HDM)/diesel exhaust particle (DEP)-induced asthma. hUC-MSC treatment attenuated lung type 2 (Th2 and type 2 innate lymphoid cell) inflammation in both models. However, these effects were only observed with particular treatment routes and timings. In vitro co-culture showed that hUC-MSC directly downregulated the interleukin (IL)-5 and IL-13 production of differentiated mouse Th2 cells and peripheral blood mononuclear cells from asthma patients. Thus, these results showed that hUC-MSC treatment can ameliorate asthma by suppressing the asthmogenic cytokine production of effector cells. However, the successful clinical application of MSCs in the future is likely to require careful optimization of the route, dosage, and timing. Korean Society for Molecular and Cellular Biology 2021-08-31 2021-08-23 /pmc/articles/PMC8424137/ /pubmed/34462397 http://dx.doi.org/10.14348/molcells.2021.0101 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. https://creativecommons.org/licenses/by-nc-sa/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ (https://creativecommons.org/licenses/by-nc-sa/3.0/)
spellingShingle Research Article
Shin, Jae Woo
Ryu, Seungwon
Ham, Jongho
Jung, Keehoon
Lee, Sangho
Chung, Doo Hyun
Kang, Hye-Ryun
Kim, Hye Young
Mesenchymal Stem Cells Suppress Severe Asthma by Directly Regulating Th2 Cells and Type 2 Innate Lymphoid Cells
title Mesenchymal Stem Cells Suppress Severe Asthma by Directly Regulating Th2 Cells and Type 2 Innate Lymphoid Cells
title_full Mesenchymal Stem Cells Suppress Severe Asthma by Directly Regulating Th2 Cells and Type 2 Innate Lymphoid Cells
title_fullStr Mesenchymal Stem Cells Suppress Severe Asthma by Directly Regulating Th2 Cells and Type 2 Innate Lymphoid Cells
title_full_unstemmed Mesenchymal Stem Cells Suppress Severe Asthma by Directly Regulating Th2 Cells and Type 2 Innate Lymphoid Cells
title_short Mesenchymal Stem Cells Suppress Severe Asthma by Directly Regulating Th2 Cells and Type 2 Innate Lymphoid Cells
title_sort mesenchymal stem cells suppress severe asthma by directly regulating th2 cells and type 2 innate lymphoid cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424137/
https://www.ncbi.nlm.nih.gov/pubmed/34462397
http://dx.doi.org/10.14348/molcells.2021.0101
work_keys_str_mv AT shinjaewoo mesenchymalstemcellssuppresssevereasthmabydirectlyregulatingth2cellsandtype2innatelymphoidcells
AT ryuseungwon mesenchymalstemcellssuppresssevereasthmabydirectlyregulatingth2cellsandtype2innatelymphoidcells
AT hamjongho mesenchymalstemcellssuppresssevereasthmabydirectlyregulatingth2cellsandtype2innatelymphoidcells
AT jungkeehoon mesenchymalstemcellssuppresssevereasthmabydirectlyregulatingth2cellsandtype2innatelymphoidcells
AT leesangho mesenchymalstemcellssuppresssevereasthmabydirectlyregulatingth2cellsandtype2innatelymphoidcells
AT chungdoohyun mesenchymalstemcellssuppresssevereasthmabydirectlyregulatingth2cellsandtype2innatelymphoidcells
AT kanghyeryun mesenchymalstemcellssuppresssevereasthmabydirectlyregulatingth2cellsandtype2innatelymphoidcells
AT kimhyeyoung mesenchymalstemcellssuppresssevereasthmabydirectlyregulatingth2cellsandtype2innatelymphoidcells