Influencing factors and strategies of enhancing nanoparticles into tumors in vivo

The administration of nanoparticles (NPs) first faces the challenges of evading renal filtration and clearance of reticuloendothelial system (RES). After that, NPs infiltrate through the expanded endothelial space and penetrated the dense stroma of tumor microenvironment to tumor cells. As long as p...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Mingming, Gao, Shan, Yang, Dongjuan, Fang, Yan, Lin, Xiaojie, Jin, Xuechao, Liu, Yuli, Liu, Xiu, Su, Kexin, Shi, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424218/
https://www.ncbi.nlm.nih.gov/pubmed/34522587
http://dx.doi.org/10.1016/j.apsb.2021.03.033
_version_ 1783749629410541568
author Zhang, Mingming
Gao, Shan
Yang, Dongjuan
Fang, Yan
Lin, Xiaojie
Jin, Xuechao
Liu, Yuli
Liu, Xiu
Su, Kexin
Shi, Kai
author_facet Zhang, Mingming
Gao, Shan
Yang, Dongjuan
Fang, Yan
Lin, Xiaojie
Jin, Xuechao
Liu, Yuli
Liu, Xiu
Su, Kexin
Shi, Kai
author_sort Zhang, Mingming
collection PubMed
description The administration of nanoparticles (NPs) first faces the challenges of evading renal filtration and clearance of reticuloendothelial system (RES). After that, NPs infiltrate through the expanded endothelial space and penetrated the dense stroma of tumor microenvironment to tumor cells. As long as possible to prolong the time of NPs remaining in tumor tissue, NPs release active agent and induce pharmacological action. This review provides a comprehensive summary of the physical and chemical properties of NPs and the influence of various biological factors in tumor microenvironment, and discusses how to improve the final efficacy through adjusting the characteristics and structure of NPs. Perspectives and future directions are also provided.
format Online
Article
Text
id pubmed-8424218
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-84242182021-09-13 Influencing factors and strategies of enhancing nanoparticles into tumors in vivo Zhang, Mingming Gao, Shan Yang, Dongjuan Fang, Yan Lin, Xiaojie Jin, Xuechao Liu, Yuli Liu, Xiu Su, Kexin Shi, Kai Acta Pharm Sin B Review The administration of nanoparticles (NPs) first faces the challenges of evading renal filtration and clearance of reticuloendothelial system (RES). After that, NPs infiltrate through the expanded endothelial space and penetrated the dense stroma of tumor microenvironment to tumor cells. As long as possible to prolong the time of NPs remaining in tumor tissue, NPs release active agent and induce pharmacological action. This review provides a comprehensive summary of the physical and chemical properties of NPs and the influence of various biological factors in tumor microenvironment, and discusses how to improve the final efficacy through adjusting the characteristics and structure of NPs. Perspectives and future directions are also provided. Elsevier 2021-08 2021-03-24 /pmc/articles/PMC8424218/ /pubmed/34522587 http://dx.doi.org/10.1016/j.apsb.2021.03.033 Text en © 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Zhang, Mingming
Gao, Shan
Yang, Dongjuan
Fang, Yan
Lin, Xiaojie
Jin, Xuechao
Liu, Yuli
Liu, Xiu
Su, Kexin
Shi, Kai
Influencing factors and strategies of enhancing nanoparticles into tumors in vivo
title Influencing factors and strategies of enhancing nanoparticles into tumors in vivo
title_full Influencing factors and strategies of enhancing nanoparticles into tumors in vivo
title_fullStr Influencing factors and strategies of enhancing nanoparticles into tumors in vivo
title_full_unstemmed Influencing factors and strategies of enhancing nanoparticles into tumors in vivo
title_short Influencing factors and strategies of enhancing nanoparticles into tumors in vivo
title_sort influencing factors and strategies of enhancing nanoparticles into tumors in vivo
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424218/
https://www.ncbi.nlm.nih.gov/pubmed/34522587
http://dx.doi.org/10.1016/j.apsb.2021.03.033
work_keys_str_mv AT zhangmingming influencingfactorsandstrategiesofenhancingnanoparticlesintotumorsinvivo
AT gaoshan influencingfactorsandstrategiesofenhancingnanoparticlesintotumorsinvivo
AT yangdongjuan influencingfactorsandstrategiesofenhancingnanoparticlesintotumorsinvivo
AT fangyan influencingfactorsandstrategiesofenhancingnanoparticlesintotumorsinvivo
AT linxiaojie influencingfactorsandstrategiesofenhancingnanoparticlesintotumorsinvivo
AT jinxuechao influencingfactorsandstrategiesofenhancingnanoparticlesintotumorsinvivo
AT liuyuli influencingfactorsandstrategiesofenhancingnanoparticlesintotumorsinvivo
AT liuxiu influencingfactorsandstrategiesofenhancingnanoparticlesintotumorsinvivo
AT sukexin influencingfactorsandstrategiesofenhancingnanoparticlesintotumorsinvivo
AT shikai influencingfactorsandstrategiesofenhancingnanoparticlesintotumorsinvivo

Ejemplares similares