Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology.

In order to elucidate the cause of acute respiratory distress syndrome of unknown etiology in a pre-pandemic patient, molecular techniques were used for detection of SARS-CoV-2. We used a SARS-CoV-2 nucleocapsid protein immunofluorescence stain to retrospectively identify an individual with diffuse...

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Autores principales: Burkett, A., McElwee, S., Margaroli, C., Bajpai, P., Elkholy, A., Manne, U., Wille, K., Benson, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424244/
https://www.ncbi.nlm.nih.gov/pubmed/34513107
http://dx.doi.org/10.1155/2021/5484239
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author Burkett, A.
McElwee, S.
Margaroli, C.
Bajpai, P.
Elkholy, A.
Manne, U.
Wille, K.
Benson, P.
author_facet Burkett, A.
McElwee, S.
Margaroli, C.
Bajpai, P.
Elkholy, A.
Manne, U.
Wille, K.
Benson, P.
author_sort Burkett, A.
collection PubMed
description In order to elucidate the cause of acute respiratory distress syndrome of unknown etiology in a pre-pandemic patient, molecular techniques were used for detection of SARS-CoV-2. We used a SARS-CoV-2 nucleocapsid protein immunofluorescence stain to retrospectively identify an individual with diffuse alveolar damage on autopsy histology who had negative respiratory virus panel results in February, 2020, in Birmingham, Alabama. In situ hybridization for SARS-CoV-2 RNA revealed evidence of widespread multiorgan SARS-CoV-2 infection. This death antecedes the first reported death of a State of Alabama resident diagnosed with SARS-CoV-2 by 26 days.
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spelling pubmed-84242442021-09-09 Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology. Burkett, A. McElwee, S. Margaroli, C. Bajpai, P. Elkholy, A. Manne, U. Wille, K. Benson, P. Case Rep Pulmonol Case Report In order to elucidate the cause of acute respiratory distress syndrome of unknown etiology in a pre-pandemic patient, molecular techniques were used for detection of SARS-CoV-2. We used a SARS-CoV-2 nucleocapsid protein immunofluorescence stain to retrospectively identify an individual with diffuse alveolar damage on autopsy histology who had negative respiratory virus panel results in February, 2020, in Birmingham, Alabama. In situ hybridization for SARS-CoV-2 RNA revealed evidence of widespread multiorgan SARS-CoV-2 infection. This death antecedes the first reported death of a State of Alabama resident diagnosed with SARS-CoV-2 by 26 days. Hindawi 2021-08-28 /pmc/articles/PMC8424244/ /pubmed/34513107 http://dx.doi.org/10.1155/2021/5484239 Text en Copyright © 2021 A. Burkett et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Burkett, A.
McElwee, S.
Margaroli, C.
Bajpai, P.
Elkholy, A.
Manne, U.
Wille, K.
Benson, P.
Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology.
title Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology.
title_full Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology.
title_fullStr Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology.
title_full_unstemmed Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology.
title_short Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology.
title_sort positive retrospective sars-cov-2 testing in a case of acute respiratory distress syndrome of unknown etiology.
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424244/
https://www.ncbi.nlm.nih.gov/pubmed/34513107
http://dx.doi.org/10.1155/2021/5484239
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