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Susceptibility of CTLA-4 −1661A/G polymorphism towards severity of rheumatic heart disease

AIM: Genetic contribution in acute rheumatic fever (ARF)/rheumatic heart disease (RHD) has been suggested but not according to severity of the valve involvement. This study attempts to identify the relevance of CTLA-4 polymorphism with severity of the disease. METHODS: In a case-control design, 291...

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Autores principales: Bansal, Ankit, Tasnim, Sana, Gupta, Mohit D., MP, Girish, Batra, Vishal, Kohli, Samantha, Tyagi, Sanjay, Pasha, M.A. Qadar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424281/
https://www.ncbi.nlm.nih.gov/pubmed/34474769
http://dx.doi.org/10.1016/j.ihj.2021.05.002
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author Bansal, Ankit
Tasnim, Sana
Gupta, Mohit D.
MP, Girish
Batra, Vishal
Kohli, Samantha
Tyagi, Sanjay
Pasha, M.A. Qadar
author_facet Bansal, Ankit
Tasnim, Sana
Gupta, Mohit D.
MP, Girish
Batra, Vishal
Kohli, Samantha
Tyagi, Sanjay
Pasha, M.A. Qadar
author_sort Bansal, Ankit
collection PubMed
description AIM: Genetic contribution in acute rheumatic fever (ARF)/rheumatic heart disease (RHD) has been suggested but not according to severity of the valve involvement. This study attempts to identify the relevance of CTLA-4 polymorphism with severity of the disease. METHODS: In a case-control design, 291 healthy controls and 83 patients were genotyped for association between RHD and single-nucleotide polymorphisms −1661A/G of CTLA-4. RESULTS: Segregation of patients on the basis of severity i.e., MVL (Mitral Valve Lesion) and CVL (Combined Valve Lesion) revealed that the frequency of CTLA-4 −1661G allele depleted as the disease progressed to CVL (p < 0.05). Patients in the age group of 31–45 years were significantly more susceptible (p < 0.046). Whereas, female patients were more susceptible than the male patients. CONCLUSION: Our study suggests the risk associated with decreased frequency of CTLA-4 −1661G allele in the CVL group and in females.
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spelling pubmed-84242812021-09-13 Susceptibility of CTLA-4 −1661A/G polymorphism towards severity of rheumatic heart disease Bansal, Ankit Tasnim, Sana Gupta, Mohit D. MP, Girish Batra, Vishal Kohli, Samantha Tyagi, Sanjay Pasha, M.A. Qadar Indian Heart J Research Brief AIM: Genetic contribution in acute rheumatic fever (ARF)/rheumatic heart disease (RHD) has been suggested but not according to severity of the valve involvement. This study attempts to identify the relevance of CTLA-4 polymorphism with severity of the disease. METHODS: In a case-control design, 291 healthy controls and 83 patients were genotyped for association between RHD and single-nucleotide polymorphisms −1661A/G of CTLA-4. RESULTS: Segregation of patients on the basis of severity i.e., MVL (Mitral Valve Lesion) and CVL (Combined Valve Lesion) revealed that the frequency of CTLA-4 −1661G allele depleted as the disease progressed to CVL (p < 0.05). Patients in the age group of 31–45 years were significantly more susceptible (p < 0.046). Whereas, female patients were more susceptible than the male patients. CONCLUSION: Our study suggests the risk associated with decreased frequency of CTLA-4 −1661G allele in the CVL group and in females. Elsevier 2021 2021-06-08 /pmc/articles/PMC8424281/ /pubmed/34474769 http://dx.doi.org/10.1016/j.ihj.2021.05.002 Text en © 2021 Cardiological Society of India. Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Brief
Bansal, Ankit
Tasnim, Sana
Gupta, Mohit D.
MP, Girish
Batra, Vishal
Kohli, Samantha
Tyagi, Sanjay
Pasha, M.A. Qadar
Susceptibility of CTLA-4 −1661A/G polymorphism towards severity of rheumatic heart disease
title Susceptibility of CTLA-4 −1661A/G polymorphism towards severity of rheumatic heart disease
title_full Susceptibility of CTLA-4 −1661A/G polymorphism towards severity of rheumatic heart disease
title_fullStr Susceptibility of CTLA-4 −1661A/G polymorphism towards severity of rheumatic heart disease
title_full_unstemmed Susceptibility of CTLA-4 −1661A/G polymorphism towards severity of rheumatic heart disease
title_short Susceptibility of CTLA-4 −1661A/G polymorphism towards severity of rheumatic heart disease
title_sort susceptibility of ctla-4 −1661a/g polymorphism towards severity of rheumatic heart disease
topic Research Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424281/
https://www.ncbi.nlm.nih.gov/pubmed/34474769
http://dx.doi.org/10.1016/j.ihj.2021.05.002
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