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Examining the utility of lower dose radiotherapy for localised primary ocular adnexal MALT lymphoma
INTRODUCTION: Most primary ocular adnexal lymphomas are those involving mucosa‐associated lymphoid tissue (MALT). Radiotherapy (RT) dose regimens in the literature vary from the historically used high doses (up to 56 Gy) to lower dose RT. We aimed to examine our institution’s experience with the use...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424308/ https://www.ncbi.nlm.nih.gov/pubmed/33675287 http://dx.doi.org/10.1002/jmrs.464 |
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author | Leeson, Sarah Jayamohan, Jayasingham Vu, Hanh Sundaresan, Puma |
author_facet | Leeson, Sarah Jayamohan, Jayasingham Vu, Hanh Sundaresan, Puma |
author_sort | Leeson, Sarah |
collection | PubMed |
description | INTRODUCTION: Most primary ocular adnexal lymphomas are those involving mucosa‐associated lymphoid tissue (MALT). Radiotherapy (RT) dose regimens in the literature vary from the historically used high doses (up to 56 Gy) to lower dose RT. We aimed to examine our institution’s experience with the use of orbital RT for treating early‐stage primary ocular adnexal MALT lymphoma (POAML). METHODS: Patients treated for stage I or II POAML over a 12‐year period (July 2006 to June 2018) were identified through institutional databases. Data were retrospectively collated through review of patient records. Descriptive statistical methods were employed to analyse the data. RESULTS: Eighteen patients (median age of 67; range 44‐87yrs) with localised POAML (3 cases of bilateral disease) were identified, resulting in a total of 21 evaluable orbits. Eight (44%) patients were female, and all were documented to be of good performance status (ECOG 0‐1). The median follow‐up was 34 months (range 8‐75 months). The commonest dose fractionation used was 20 Gy in 10 fractions (n = 13 orbits) and a 3D conformal or volumetric modulated arc therapy (VMAT) technique was used in the majority of cases. None of the patients experienced an in‐field recurrence. One patient had experienced a contralateral orbital recurrence two years post‐unilateral orbital RT for orbital MALT lymphoma. Three patients experienced distant relapse. CONCLUSION: The use of lower dose orbital RT such as 20 Gy in 10 fractions (or radio biologically equivalent) yields excellent local disease control in the management of ocular adnexal MALT lymphoma. The durability of the response appears to be favourable. Given the indolent nature of the disease and the low levels of toxicity associated with lower dose orbital RT, this regimen remains our favoured approach to the management of localised POAML. |
format | Online Article Text |
id | pubmed-8424308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84243082021-09-13 Examining the utility of lower dose radiotherapy for localised primary ocular adnexal MALT lymphoma Leeson, Sarah Jayamohan, Jayasingham Vu, Hanh Sundaresan, Puma J Med Radiat Sci Original Articles INTRODUCTION: Most primary ocular adnexal lymphomas are those involving mucosa‐associated lymphoid tissue (MALT). Radiotherapy (RT) dose regimens in the literature vary from the historically used high doses (up to 56 Gy) to lower dose RT. We aimed to examine our institution’s experience with the use of orbital RT for treating early‐stage primary ocular adnexal MALT lymphoma (POAML). METHODS: Patients treated for stage I or II POAML over a 12‐year period (July 2006 to June 2018) were identified through institutional databases. Data were retrospectively collated through review of patient records. Descriptive statistical methods were employed to analyse the data. RESULTS: Eighteen patients (median age of 67; range 44‐87yrs) with localised POAML (3 cases of bilateral disease) were identified, resulting in a total of 21 evaluable orbits. Eight (44%) patients were female, and all were documented to be of good performance status (ECOG 0‐1). The median follow‐up was 34 months (range 8‐75 months). The commonest dose fractionation used was 20 Gy in 10 fractions (n = 13 orbits) and a 3D conformal or volumetric modulated arc therapy (VMAT) technique was used in the majority of cases. None of the patients experienced an in‐field recurrence. One patient had experienced a contralateral orbital recurrence two years post‐unilateral orbital RT for orbital MALT lymphoma. Three patients experienced distant relapse. CONCLUSION: The use of lower dose orbital RT such as 20 Gy in 10 fractions (or radio biologically equivalent) yields excellent local disease control in the management of ocular adnexal MALT lymphoma. The durability of the response appears to be favourable. Given the indolent nature of the disease and the low levels of toxicity associated with lower dose orbital RT, this regimen remains our favoured approach to the management of localised POAML. John Wiley and Sons Inc. 2021-03-06 2021-09 /pmc/articles/PMC8424308/ /pubmed/33675287 http://dx.doi.org/10.1002/jmrs.464 Text en © 2021 The Authors. Journal of Medical Radiation Sciences published by John Wiley & Sons Australia, Ltd on behalf of Australian Society of Medical Imaging and Radiation Therapy and New Zealand Institute of Medical Radiation Technology https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Leeson, Sarah Jayamohan, Jayasingham Vu, Hanh Sundaresan, Puma Examining the utility of lower dose radiotherapy for localised primary ocular adnexal MALT lymphoma |
title | Examining the utility of lower dose radiotherapy for localised primary ocular adnexal MALT lymphoma |
title_full | Examining the utility of lower dose radiotherapy for localised primary ocular adnexal MALT lymphoma |
title_fullStr | Examining the utility of lower dose radiotherapy for localised primary ocular adnexal MALT lymphoma |
title_full_unstemmed | Examining the utility of lower dose radiotherapy for localised primary ocular adnexal MALT lymphoma |
title_short | Examining the utility of lower dose radiotherapy for localised primary ocular adnexal MALT lymphoma |
title_sort | examining the utility of lower dose radiotherapy for localised primary ocular adnexal malt lymphoma |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424308/ https://www.ncbi.nlm.nih.gov/pubmed/33675287 http://dx.doi.org/10.1002/jmrs.464 |
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