T cell-oriented strategies for controlling the COVID-19 pandemic

COVID-19 vaccination programmes are ongoing worldwide. Neutralizing antibodies are thought to be key for host protection against COVID-19; however, strategies that focus only on neutralizing antibodies may not be sufficient to cope with the pandemic in the longer term owing to the decay of antibody...

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Autores principales: Noh, Ji Yun, Jeong, Hye Won, Kim, Jerome H., Shin, Eui-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424399/
https://www.ncbi.nlm.nih.gov/pubmed/34497383
http://dx.doi.org/10.1038/s41577-021-00625-9
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author Noh, Ji Yun
Jeong, Hye Won
Kim, Jerome H.
Shin, Eui-Cheol
author_facet Noh, Ji Yun
Jeong, Hye Won
Kim, Jerome H.
Shin, Eui-Cheol
author_sort Noh, Ji Yun
collection PubMed
description COVID-19 vaccination programmes are ongoing worldwide. Neutralizing antibodies are thought to be key for host protection against COVID-19; however, strategies that focus only on neutralizing antibodies may not be sufficient to cope with the pandemic in the longer term owing to the decay of antibody titres and the emergence of antibody-escape variants of SARS-CoV-2. Here, we describe the protective roles of T cells in COVID-19 and the conservation of T cell epitopes in SARS-CoV-2 variants of concern, and discuss the potential contribution of T cell-oriented strategies to controlling the COVID-19 pandemic.
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spelling pubmed-84243992021-09-08 T cell-oriented strategies for controlling the COVID-19 pandemic Noh, Ji Yun Jeong, Hye Won Kim, Jerome H. Shin, Eui-Cheol Nat Rev Immunol Comment COVID-19 vaccination programmes are ongoing worldwide. Neutralizing antibodies are thought to be key for host protection against COVID-19; however, strategies that focus only on neutralizing antibodies may not be sufficient to cope with the pandemic in the longer term owing to the decay of antibody titres and the emergence of antibody-escape variants of SARS-CoV-2. Here, we describe the protective roles of T cells in COVID-19 and the conservation of T cell epitopes in SARS-CoV-2 variants of concern, and discuss the potential contribution of T cell-oriented strategies to controlling the COVID-19 pandemic. Nature Publishing Group UK 2021-09-08 2021 /pmc/articles/PMC8424399/ /pubmed/34497383 http://dx.doi.org/10.1038/s41577-021-00625-9 Text en © Springer Nature Limited 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
Noh, Ji Yun
Jeong, Hye Won
Kim, Jerome H.
Shin, Eui-Cheol
T cell-oriented strategies for controlling the COVID-19 pandemic
title T cell-oriented strategies for controlling the COVID-19 pandemic
title_full T cell-oriented strategies for controlling the COVID-19 pandemic
title_fullStr T cell-oriented strategies for controlling the COVID-19 pandemic
title_full_unstemmed T cell-oriented strategies for controlling the COVID-19 pandemic
title_short T cell-oriented strategies for controlling the COVID-19 pandemic
title_sort t cell-oriented strategies for controlling the covid-19 pandemic
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424399/
https://www.ncbi.nlm.nih.gov/pubmed/34497383
http://dx.doi.org/10.1038/s41577-021-00625-9
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