Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice

Pharmacogenomics (PGx) studies the use of genetic data to optimize drug therapy. Numerous clinical centers have commenced implementing pharmacogenetic tests in clinical routines. Next-generation sequencing (NGS) technologies are emerging as a more comprehensive and time- and cost-effective approach...

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Autores principales: Tafazoli, Alireza, Guchelaar, Henk-Jan, Miltyk, Wojciech, Kretowski, Adam J., Swen, Jesse J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424415/
https://www.ncbi.nlm.nih.gov/pubmed/34512329
http://dx.doi.org/10.3389/fphar.2021.693453
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author Tafazoli, Alireza
Guchelaar, Henk-Jan
Miltyk, Wojciech
Kretowski, Adam J.
Swen, Jesse J.
author_facet Tafazoli, Alireza
Guchelaar, Henk-Jan
Miltyk, Wojciech
Kretowski, Adam J.
Swen, Jesse J.
author_sort Tafazoli, Alireza
collection PubMed
description Pharmacogenomics (PGx) studies the use of genetic data to optimize drug therapy. Numerous clinical centers have commenced implementing pharmacogenetic tests in clinical routines. Next-generation sequencing (NGS) technologies are emerging as a more comprehensive and time- and cost-effective approach in PGx. This review presents the main considerations for applying NGS in guiding drug treatment in clinical practice. It discusses both the advantages and the challenges of implementing NGS-based tests in PGx. Moreover, the limitations of each NGS platform are revealed, and the solutions for setting up and management of these technologies in clinical practice are addressed.
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spelling pubmed-84244152021-09-09 Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice Tafazoli, Alireza Guchelaar, Henk-Jan Miltyk, Wojciech Kretowski, Adam J. Swen, Jesse J. Front Pharmacol Pharmacology Pharmacogenomics (PGx) studies the use of genetic data to optimize drug therapy. Numerous clinical centers have commenced implementing pharmacogenetic tests in clinical routines. Next-generation sequencing (NGS) technologies are emerging as a more comprehensive and time- and cost-effective approach in PGx. This review presents the main considerations for applying NGS in guiding drug treatment in clinical practice. It discusses both the advantages and the challenges of implementing NGS-based tests in PGx. Moreover, the limitations of each NGS platform are revealed, and the solutions for setting up and management of these technologies in clinical practice are addressed. Frontiers Media S.A. 2021-08-25 /pmc/articles/PMC8424415/ /pubmed/34512329 http://dx.doi.org/10.3389/fphar.2021.693453 Text en Copyright © 2021 Tafazoli, Guchelaar, Miltyk, Kretowski and Swen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Tafazoli, Alireza
Guchelaar, Henk-Jan
Miltyk, Wojciech
Kretowski, Adam J.
Swen, Jesse J.
Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice
title Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice
title_full Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice
title_fullStr Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice
title_full_unstemmed Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice
title_short Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice
title_sort applying next-generation sequencing platforms for pharmacogenomic testing in clinical practice
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424415/
https://www.ncbi.nlm.nih.gov/pubmed/34512329
http://dx.doi.org/10.3389/fphar.2021.693453
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