Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma

The ability to adapt to environmental stress, including therapeutic insult, contributes to tumor evolution and drug resistance. In suboptimal conditions, the integrated stress response (ISR) promotes survival by dampening cytosolic translation. We show that ISR-dependent survival also relies on a co...

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Detalles Bibliográficos
Autores principales: Vendramin, Roberto, Katopodi, Vicky, Cinque, Sonia, Konnova, Angelina, Knezevic, Zorica, Adnane, Sara, Verheyden, Yvessa, Karras, Panagiotis, Demesmaeker, Ewout, Bosisio, Francesca M., Kucera, Lukas, Rozman, Jan, Gladwyn-Ng, Ivan, Rizzotto, Lara, Dassi, Erik, Millevoi, Stefania, Bechter, Oliver, Marine, Jean-Christophe, Leucci, Eleonora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424468/
https://www.ncbi.nlm.nih.gov/pubmed/34287642
http://dx.doi.org/10.1084/jem.20210571

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