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Influence of food on pharmacokinetics and pharmacodynamics of 4-phenylbutyrate in patients with urea cycle disorders

Urea cycle disorders (UCDs), inborn errors of hepatocyte metabolism, cause hyperammonemia and lead to neurocognitive deficits, coma, and even death. Sodium 4-phenylbutyrate (NaPB), a standard adjunctive therapy for UCDs, generates an alternative pathway of nitrogen deposition through glutamine consu...

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Detalles Bibliográficos
Autores principales:	Nakajima, Yoko, Osaka, Shuhei, Mizuno, Tadahaya, Yokoi, Katsuyuki, Nakano, Satoshi, Hirai, Saeko, Hiraoka, Yuka, Miura, Yoshiki, Suzuki, Mitsuyoshi, Kusuhara, Hiroyuki, Hayashi, Hisamitsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424592/ https://www.ncbi.nlm.nih.gov/pubmed/34522617 http://dx.doi.org/10.1016/j.ymgmr.2021.100799

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