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Drug–Polymer Interactions in Acetaminophen/Hydroxypropylmethylcellulose Acetyl Succinate Amorphous Solid Dispersions Revealed by Multidimensional Multinuclear Solid-State NMR Spectroscopy

[Image: see text] The bioavailability of insoluble crystalline active pharmaceutical ingredients (APIs) can be enhanced by formulation as amorphous solid dispersions (ASDs). One of the key factors of ASD stabilization is the formation of drug–polymer interactions at the molecular level. Here, we use...

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Detalles Bibliográficos
Autores principales:	Pugliese, Andrea, Toresco, Michael, McNamara, Daniel, Iuga, Dinu, Abraham, Anuji, Tobyn, Michael, Hawarden, Lucy E., Blanc, Frédéric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424625/ https://www.ncbi.nlm.nih.gov/pubmed/34375100 http://dx.doi.org/10.1021/acs.molpharmaceut.1c00427

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