Chemical “Butterfly Effect” Explaining the Coordination Chemistry and Antimicrobial Properties of Clavanin Complexes

[Image: see text] Can a minor difference in the nonmetal binding sequence of antimicrobial clavanins explain the drastic change in the coordination environment and antimicrobial efficiency? This study answers the question with a definite “yes”, showing the details of the bioinorganic chemistry of Zn...

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Detalles Bibliográficos
Autores principales: Miller, Adriana, Matera-Witkiewicz, Agnieszka, Mikołajczyk, Aleksandra, Wieczorek, Robert, Rowińska-Żyrek, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424629/
https://www.ncbi.nlm.nih.gov/pubmed/34382773
http://dx.doi.org/10.1021/acs.inorgchem.1c02101
Descripción
Sumario:[Image: see text] Can a minor difference in the nonmetal binding sequence of antimicrobial clavanins explain the drastic change in the coordination environment and antimicrobial efficiency? This study answers the question with a definite “yes”, showing the details of the bioinorganic chemistry of Zn(II) and Cu(II) complexes with clavanins, histidine-rich, antimicrobial peptides from hemocytes of the tunicate Styela clava.

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