FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington’s disease

CAG repeat expansion in the HTT gene drives Huntington’s disease (HD) pathogenesis and is modulated by DNA damage repair pathways. In this context, the interaction between FAN1, a DNA-structure-specific nuclease, and MLH1, member of the DNA mismatch repair pathway (MMR), is not defined. Here, we ide...

Descripción completa

Detalles Bibliográficos
Autores principales: Goold, Robert, Hamilton, Joseph, Menneteau, Thomas, Flower, Michael, Bunting, Emma L., Aldous, Sarah G., Porro, Antonio, Vicente, José R., Allen, Nicholas D., Wilkinson, Hilary, Bates, Gillian P., Sartori, Alessandro A., Thalassinos, Konstantinos, Balmus, Gabriel, Tabrizi, Sarah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424649/
https://www.ncbi.nlm.nih.gov/pubmed/34469738
http://dx.doi.org/10.1016/j.celrep.2021.109649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424649/
https://www.ncbi.nlm.nih.gov/pubmed/34469738
http://dx.doi.org/10.1016/j.celrep.2021.109649

Ejemplares similares