Cargando…

FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington’s disease

CAG repeat expansion in the HTT gene drives Huntington’s disease (HD) pathogenesis and is modulated by DNA damage repair pathways. In this context, the interaction between FAN1, a DNA-structure-specific nuclease, and MLH1, member of the DNA mismatch repair pathway (MMR), is not defined. Here, we ide...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goold, Robert, Hamilton, Joseph, Menneteau, Thomas, Flower, Michael, Bunting, Emma L., Aldous, Sarah G., Porro, Antonio, Vicente, José R., Allen, Nicholas D., Wilkinson, Hilary, Bates, Gillian P., Sartori, Alessandro A., Thalassinos, Konstantinos, Balmus, Gabriel, Tabrizi, Sarah J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424649/ https://www.ncbi.nlm.nih.gov/pubmed/34469738 http://dx.doi.org/10.1016/j.celrep.2021.109649

Ejemplares similares

FAN1 modifies Huntington’s disease progression by stabilizing the expanded HTT CAG repeat
por: Goold, Robert, et al.
Publicado: (2019)

Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches
por: Pinto, Ricardo Mouro, et al.
Publicado: (2013)

FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats
por: Porro, Antonio, et al.
Publicado: (2021)

Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington’s disease knock-in mice is blocked by Mlh1 knock-out
por: Loupe, Jacob M, et al.
Publicado: (2020)

Exome sequencing of individuals with Huntington’s disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset
por: McAllister, Branduff, et al.
Publicado: (2022)

Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection
por: Roy, Jennie C L, et al.
Publicado: (2021)

A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes
por: Ciosi, Marc, et al.
Publicado: (2019)

Intermediate CAG Repeats in Huntington's Disease: Analysis of COHORT
por: Ha, Ainhi D., et al.
Publicado: (2012)

What is the Pathogenic CAG Expansion Length in Huntington’s Disease?
por: Donaldson, Jasmine, et al.
Publicado: (2021)

CAG Somatic Instability in a Huntington Disease Expansion Carrier Presenting with a Progressive Supranuclear Palsy‐like Phenotype
por: Dewan, Ramita, et al.
Publicado: (2022)

Mlh2 Is an Accessory Factor for DNA Mismatch Repair in Saccharomyces cerevisiae
por: Campbell, Christopher S., et al.
Publicado: (2014)

Late-onset Huntington’s disease with 40–42 CAG expansion
por: Capiluppi, Elisa, et al.
Publicado: (2019)

The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans
por: Manhart, Carol M., et al.
Publicado: (2017)

CAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset
Publicado: (2019)

Reduction of Huntington’s Disease RNA Foci by CAG Repeat-Targeting Reagents
por: Urbanek, Martyna O., et al.
Publicado: (2017)

Parkinsonism with a Hint of Huntington’s from 29 CAG Repeats in HTT
por: JOT, Sipilä
Publicado: (2019)

Case report and literature review of Huntington disease with intermediate CAG expansion
por: Jevtic, Stefan D, et al.
Publicado: (2020)

DNA mismatch repair gene MLH1 induces apoptosis in prostate cancer cells
por: Fukuhara, Shinichiro, et al.
Publicado: (2014)

Handcuffing intrinsically disordered regions in Mlh1–Pms1 disrupts mismatch repair
por: Furman, Christopher M, et al.
Publicado: (2021)

DNA Polymerases as Potential Therapeutic Targets for Cancers Deficient in the DNA Mismatch Repair Proteins MSH2 or MLH1
por: Martin, Sarah A., et al.
Publicado: (2010)

Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington’s Disease Knock-In Mice
por: Neto, João Luís, et al.
Publicado: (2017)

Huntington’s disease mouse models: unraveling the pathology caused by CAG repeat expansion
por: Kaye, Julia, et al.
Publicado: (2021)

Millennial soil retention of terrestrial organic matter deposited in the Bengal Fan
por: French, Katherine L., et al.
Publicado: (2018)

Mutations in the MutSα interaction interface of MLH1 can abolish DNA mismatch repair
por: Plotz, Guido, et al.
Publicado: (2006)

Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein
por: Dominguez-Valentin, Mev, et al.
Publicado: (2014)

Estrogen enhances mismatch repair by induction of MLH1 expression via estrogen receptor-β
por: Lu, Jun-Yu, et al.
Publicado: (2017)

MLH1 promoter hypermethylation predicts poorer prognosis in mismatch repair deficiency endometrial carcinomas
por: Kaneko, Enami, et al.
Publicado: (2021)

Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair
por: DuPrie, Matthew L., et al.
Publicado: (2022)

FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders
por: Deshmukh, Amit L., et al.
Publicado: (2021)

Continuous and Periodic Expansion of CAG Repeats in Huntington's Disease R6/1 Mice
por: Møllersen, Linda, et al.
Publicado: (2010)

CAG-Expansion Haplotype Analysis in a Population with a Low Prevalence of Huntington's Disease
por: Pulkes, Teeratorn, et al.
Publicado: (2014)

Problems and solutions for the analysis of somatic CAG repeat expansion and their relationship to Huntington's disease toxicity
por: Budworth, Helen, et al.
Publicado: (2016)

The Association between CAG Repeat Length and Age of Onset of Juvenile-Onset Huntington’s Disease
por: Schultz, Jordan L., et al.
Publicado: (2020)

CAG Repeat Instability in the Peripheral and Central Nervous System of Transgenic Huntington’s Disease Monkeys
por: Cho, In K., et al.
Publicado: (2022)

CAG repeat expansion in the Huntington’s disease gene shapes linear and circular RNAs biogenesis
por: Ayyildiz, Dilara, et al.
Publicado: (2023)

Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1
por: He, Wei, et al.
Publicado: (2008)

Activation of Saccharomyces cerevisiae Mlh1-Pms1 Endonuclease in a Reconstituted Mismatch Repair System
por: Smith, Catherine E., et al.
Publicado: (2015)

DNA mismatch repair protein Mlh1 is required for tetravalent chromium intermediate-induced DNA damage
por: Wakeman, Timothy P., et al.
Publicado: (2017)

Mismatch repair protein and MLH1 methylation status as predictors of response to adjuvant therapy in endometrial cancer
por: Loukovaara, Mikko, et al.
Publicado: (2021)

Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function
por: Reyes, Gloria X., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0n40t5b7jhcos5om7bfvhl5ksf