Interstitial lung disease occurring shortly after tocilizumab infusion in a patient with polyarticular juvenile idiopathic arthritis: a case report

BACKGROUND: Tocilizumab has been shown to be effective for treatment of juvenile idiopathic arthritis (JIA). To our knowledge, this is the first reported case of interstitial lung disease occurring shortly after tocilizumab infusion in a patient with JIA. CASE PRESENTATION: A 14-year-old female pati...

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Autores principales: Sugihara, Koichi, Wakiya, Risa, Shimada, Hiromi, Kato, Mikiya, Kameda, Tomohiro, Nakashima, Shusaku, Mansour, Mai Mahmoud Fahmy, Ushio, Yusuke, Kadowaki, Norimitsu, Dobashi, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424947/
https://www.ncbi.nlm.nih.gov/pubmed/34496961
http://dx.doi.org/10.1186/s13223-021-00594-7
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author Sugihara, Koichi
Wakiya, Risa
Shimada, Hiromi
Kato, Mikiya
Kameda, Tomohiro
Nakashima, Shusaku
Mansour, Mai Mahmoud Fahmy
Ushio, Yusuke
Kadowaki, Norimitsu
Dobashi, Hiroaki
author_facet Sugihara, Koichi
Wakiya, Risa
Shimada, Hiromi
Kato, Mikiya
Kameda, Tomohiro
Nakashima, Shusaku
Mansour, Mai Mahmoud Fahmy
Ushio, Yusuke
Kadowaki, Norimitsu
Dobashi, Hiroaki
author_sort Sugihara, Koichi
collection PubMed
description BACKGROUND: Tocilizumab has been shown to be effective for treatment of juvenile idiopathic arthritis (JIA). To our knowledge, this is the first reported case of interstitial lung disease occurring shortly after tocilizumab infusion in a patient with JIA. CASE PRESENTATION: A 14-year-old female patient with polyarticular JIA developed interstitial lung disease after intravenous and subcutaneous administration of tocilizumab. Her condition improved with glucocorticoid therapy. CONCLUSION: Our results suggest that increased interleukin-6 levels in the blood following tocilizumab treatment may be linked to development of interstitial lung disease.
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spelling pubmed-84249472021-09-10 Interstitial lung disease occurring shortly after tocilizumab infusion in a patient with polyarticular juvenile idiopathic arthritis: a case report Sugihara, Koichi Wakiya, Risa Shimada, Hiromi Kato, Mikiya Kameda, Tomohiro Nakashima, Shusaku Mansour, Mai Mahmoud Fahmy Ushio, Yusuke Kadowaki, Norimitsu Dobashi, Hiroaki Allergy Asthma Clin Immunol Case Report BACKGROUND: Tocilizumab has been shown to be effective for treatment of juvenile idiopathic arthritis (JIA). To our knowledge, this is the first reported case of interstitial lung disease occurring shortly after tocilizumab infusion in a patient with JIA. CASE PRESENTATION: A 14-year-old female patient with polyarticular JIA developed interstitial lung disease after intravenous and subcutaneous administration of tocilizumab. Her condition improved with glucocorticoid therapy. CONCLUSION: Our results suggest that increased interleukin-6 levels in the blood following tocilizumab treatment may be linked to development of interstitial lung disease. BioMed Central 2021-09-08 /pmc/articles/PMC8424947/ /pubmed/34496961 http://dx.doi.org/10.1186/s13223-021-00594-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Sugihara, Koichi
Wakiya, Risa
Shimada, Hiromi
Kato, Mikiya
Kameda, Tomohiro
Nakashima, Shusaku
Mansour, Mai Mahmoud Fahmy
Ushio, Yusuke
Kadowaki, Norimitsu
Dobashi, Hiroaki
Interstitial lung disease occurring shortly after tocilizumab infusion in a patient with polyarticular juvenile idiopathic arthritis: a case report
title Interstitial lung disease occurring shortly after tocilizumab infusion in a patient with polyarticular juvenile idiopathic arthritis: a case report
title_full Interstitial lung disease occurring shortly after tocilizumab infusion in a patient with polyarticular juvenile idiopathic arthritis: a case report
title_fullStr Interstitial lung disease occurring shortly after tocilizumab infusion in a patient with polyarticular juvenile idiopathic arthritis: a case report
title_full_unstemmed Interstitial lung disease occurring shortly after tocilizumab infusion in a patient with polyarticular juvenile idiopathic arthritis: a case report
title_short Interstitial lung disease occurring shortly after tocilizumab infusion in a patient with polyarticular juvenile idiopathic arthritis: a case report
title_sort interstitial lung disease occurring shortly after tocilizumab infusion in a patient with polyarticular juvenile idiopathic arthritis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424947/
https://www.ncbi.nlm.nih.gov/pubmed/34496961
http://dx.doi.org/10.1186/s13223-021-00594-7
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