Recovering genotypes and phenotypes using allele-specific genes

With the recent increase in RNA sequencing efforts using large cohorts of individuals, surveying allele-specific gene expression is becoming increasingly frequent. Here, we report that, despite not containing explicit variant information, a list of genes known to be allele-specific in an individual...

Descripción completa

Detalles Bibliográficos
Autores principales: Gürsoy, Gamze, Lu, Nancy, Wagner, Sarah, Gerstein, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425091/
https://www.ncbi.nlm.nih.gov/pubmed/34493313
http://dx.doi.org/10.1186/s13059-021-02477-x
_version_ 1783749788602204160
author Gürsoy, Gamze
Lu, Nancy
Wagner, Sarah
Gerstein, Mark
author_facet Gürsoy, Gamze
Lu, Nancy
Wagner, Sarah
Gerstein, Mark
author_sort Gürsoy, Gamze
collection PubMed
description With the recent increase in RNA sequencing efforts using large cohorts of individuals, surveying allele-specific gene expression is becoming increasingly frequent. Here, we report that, despite not containing explicit variant information, a list of genes known to be allele-specific in an individual is enough to recover key variants and link the individuals back to their genotypes and phenotypes. This creates a privacy conundrum. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-021-02477-x.
format Online
Article
Text
id pubmed-8425091
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-84250912021-09-10 Recovering genotypes and phenotypes using allele-specific genes Gürsoy, Gamze Lu, Nancy Wagner, Sarah Gerstein, Mark Genome Biol Short Report With the recent increase in RNA sequencing efforts using large cohorts of individuals, surveying allele-specific gene expression is becoming increasingly frequent. Here, we report that, despite not containing explicit variant information, a list of genes known to be allele-specific in an individual is enough to recover key variants and link the individuals back to their genotypes and phenotypes. This creates a privacy conundrum. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-021-02477-x. BioMed Central 2021-09-07 /pmc/articles/PMC8425091/ /pubmed/34493313 http://dx.doi.org/10.1186/s13059-021-02477-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Short Report
Gürsoy, Gamze
Lu, Nancy
Wagner, Sarah
Gerstein, Mark
Recovering genotypes and phenotypes using allele-specific genes
title Recovering genotypes and phenotypes using allele-specific genes
title_full Recovering genotypes and phenotypes using allele-specific genes
title_fullStr Recovering genotypes and phenotypes using allele-specific genes
title_full_unstemmed Recovering genotypes and phenotypes using allele-specific genes
title_short Recovering genotypes and phenotypes using allele-specific genes
title_sort recovering genotypes and phenotypes using allele-specific genes
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425091/
https://www.ncbi.nlm.nih.gov/pubmed/34493313
http://dx.doi.org/10.1186/s13059-021-02477-x
work_keys_str_mv AT gursoygamze recoveringgenotypesandphenotypesusingallelespecificgenes
AT lunancy recoveringgenotypesandphenotypesusingallelespecificgenes
AT wagnersarah recoveringgenotypesandphenotypesusingallelespecificgenes
AT gersteinmark recoveringgenotypesandphenotypesusingallelespecificgenes

Ejemplares similares